a(GO:"neurofibrillary tangle") decreases bp(GO:"apoptotic process")

View Subject View Object

PubMed:30126037

NFT containing neurons upregulated genes involved in cell survival and viability, inflammation, cell cycle progression and molecular transport and downregulated apoptosis, necrosis and cell death pathways (Figure 1a). NFkB, a pro-survival master transcriptional regulator of inflammation, was the highest predicted upstream regulator of the NFT-gene expression profile. In agreement with inflammatory activation, other predicted upstream regulators included IFNG, TNF, TLR4, IL1B and CXCL1 (Figure 1b)

Related Edges 11

• a(GO:"neurofibrillary tangle") decreases bp(GO:"cell death")
• a(GO:"neurofibrillary tangle") increases bp(MESH:"Cell Survival")
• a(GO:"neurofibrillary tangle") increases bp(GO:"inflammatory response")
• a(GO:"neurofibrillary tangle") increases bp(GO:"cell cycle")
• a(GO:"neurofibrillary tangle") decreases path(MESH:Necrosis)
• a(GO:"neurofibrillary tangle") increases p(HGNC:NFKB1)
• a(GO:"neurofibrillary tangle") increases p(HGNC:IFNG)
• a(GO:"neurofibrillary tangle") increases p(HGNC:TNF)
• a(GO:"neurofibrillary tangle") increases p(HGNC:TLR4)
• a(GO:"neurofibrillary tangle") increases p(HGNC:IL1B)
• a(GO:"neurofibrillary tangle") increases p(HGNC:CXCL1)

Confidence

Medium

MeSH

Neurons

MeSH

Alzheimer Disease

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---