path(MESH:Tauopathies) association path(MESH:"Supranuclear Palsy, Progressive")

View Subject View Object

PubMed:30126037

PSP is an age-associated tauopathy that clinically manifests as parkinsonism with additional motor abnormalities and cognitive dysfunction (Orr et al., 2017), and is neuropathologically defined by accumulation of four-repeat (4R) tau, NFTs, gliosis and neurodegeneration (Flament et al., 1991)

Related Edges 9

• path(MESH:"Parkinsonian Disorders") association path(MESH:"Supranuclear Palsy, Progressive")
• path(MESH:"Supranuclear Palsy, Progressive") increases a(HBP:HBP00045)
• path(MESH:"Supranuclear Palsy, Progressive") increases a(GO:"neurofibrillary tangle")
• path(MESH:"Supranuclear Palsy, Progressive") increases bp(HP:Neurodegeneration)
• path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:Gliosis)
• path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Motor Disorders")
• path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:"Parkinsonian Disorders")
• path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:Tauopathies)
• path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Cognitive Dysfunction")

Confidence

Medium

MeSH

Cerebral Cortex

MeSH

Hippocampus

MeSH

Supranuclear Palsy, Progressive

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---