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Porphyria, Erythropoietic

Name
Porphyria, Erythropoietic
Namespace Keyword
MeSHDisease
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno

Sample Annotated Edges 5

a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Using isolated duodenal loops to measure the transepithelial iron transport, we found that CEP mice presented a higher rate of iron absorption than the WT mice, although the differences between the area under the curves did not reach statistical significance (Figure 3D). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
bone marrow cell
MeSH
Duodenum
MeSH
Porphyria, Erythropoietic
Text Location
Results

a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Serum iron was also increased in CEP mice, but this did not lead to elevated Tf saturation because Tf was also significantly increased, which is reminiscent of iron deficiency anemia and facilitates iron delivery to a larger number of erythroblasts (Table 1 and Figure 3G). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
bone marrow cell
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Iron was also detected in the macrophages of the red pulp of CEP mice, while almost no iron deposit was observed in the spleen of Hjv–/– mice (Figure 4B), confirming that Hb and “free” heme are the likely source of macrophage iron accumulation. PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

As expected, Perl’s staining of CEP kidneys showed significant accumulation of iron in the renal cortical part, particularly in the proximal tubules (Figure 6A). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

a(CHEBI:heme) increases a(CHEBI:"iron(2+)") View Subject | View Object

Iron was also detected in the macrophages of the red pulp of CEP mice, while almost no iron deposit was observed in the spleen of Hjv–/– mice (Figure 4B), confirming that Hb and “free” heme are the likely source of macrophage iron accumulation. PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Serum
MeSH
Porphyria, Erythropoietic
Text Location
Results

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About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.