1. Catalog
  2. Nodes
  3. p(HGNC:ATF6)

p(HGNC:ATF6)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
ATF6
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

The Biology of Proteostasis in Aging and Disease v1.0.0

In-Edges 5

bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(p(HGNC:ATF6), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(MESH:"Golgi Apparatus")) View Subject | View Object

In parallel, ER stress promotes the relocation of ATF6 from the ER membrane to the Golgi apparatus, where it is cleaved by SP1 and SP2 proteases. PubMed:25784053

Appears in Networks:

p(HGNC:PRSS1) decreases p(HGNC:ATF6) View Subject | View Object

In parallel, ER stress promotes the relocation of ATF6 from the ER membrane to the Golgi apparatus, where it is cleaved by SP1 and SP2 proteases. PubMed:25784053

Appears in Networks:
Annotations
MeSH
Golgi Apparatus

p(HGNC:PRSS2) decreases p(HGNC:ATF6) View Subject | View Object

In parallel, ER stress promotes the relocation of ATF6 from the ER membrane to the Golgi apparatus, where it is cleaved by SP1 and SP2 proteases. PubMed:25784053

Appears in Networks:
Annotations
MeSH
Golgi Apparatus

path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation p(HGNC:ATF6) View Subject | View Object

Disruption of the ATF6 arm of the UPR(ER) is reported to occur in mouse models of HD and a VAPB cell model of ALS, suggesting that differential changes in UPR arms may be a feature of disease progression (102, 103). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

path(MESH:"Huntington Disease") negativeCorrelation p(HGNC:ATF6) View Subject | View Object

Disruption of the ATF6 arm of the UPR(ER) is reported to occur in mouse models of HD and a VAPB cell model of ALS, suggesting that differential changes in UPR arms may be a feature of disease progression (102, 103). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

Out-Edges 2

p(HGNC:ATF6) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") View Subject | View Object

Disruption of the ATF6 arm of the UPR(ER) is reported to occur in mouse models of HD and a VAPB cell model of ALS, suggesting that differential changes in UPR arms may be a feature of disease progression (102, 103). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

p(HGNC:ATF6) negativeCorrelation path(MESH:"Huntington Disease") View Subject | View Object

Disruption of the ATF6 arm of the UPR(ER) is reported to occur in mouse models of HD and a VAPB cell model of ALS, suggesting that differential changes in UPR arms may be a feature of disease progression (102, 103). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.