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p(HGNC:F8)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
F8
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

a(CHEBI:heme) decreases act(p(HGNC:F8)) View Subject | View Object

Heme significantly reduced FVIII cofactor activity by inhibiting its interaction with activated factor IX(FIXa) in vitro. PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

a(CHEBI:heme) decreases p(HGNC:F8) View Subject | View Object

Taken sequentially, it appears that the release of heme under hemolytic conditions initiates the extrinsic pathway of coagulation through the upregulation of TF on endothelial cells and leukocytes, but subsequently blocks the propagation of coagulation by inhibiting FVIII and FV, and by inhibiting the conversion of fibrinogen into fibrin and fibrin clots. PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

p(HGNC:VWF) decreases deg(p(HGNC:F8)) View Subject | View Object

In humans and mice, VWF protects FVIII from degradation by proteases in the circulation and controls FVIII catabolism [43]. PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.