p(HGNC:VWF)
In endothelial cells, heme induces TLR4-dependent degranulation of Weibel–Palade bodies and P-selectins and VWF release. PubMed:24904418
For example, haem stimulates expression of P-selectin and von Willebrand Factor (VWF) ‘strings’ on endothelial cells in vitro and on the vessel walls of both normal and SCD mice (Belcher et al, 2014). PubMed:25307023
Circulating MPs in PNH express the endothelial markers ICAM-1 (CD54), sVCAM-1, VWF, CD144, and CD105, indicating endothelial activation [24]. PubMed:29929138
The VWF is prothrombotic and can increase the adhesion of erythrocytes to the endothelium. PubMed:24904418
The VWF is prothrombotic and can increase the adhesion of erythrocytes to the endothelium. PubMed:24904418
In humans and mice, VWF protects FVIII from degradation by proteases in the circulation and controls FVIII catabolism [43]. PubMed:26875449
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.