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p(HGNC:VPS35)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
VPS35
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

In-Edges 1

complex(p(HGNC:SORL1), p(HGNC:VPS35)) hasComponent p(HGNC:VPS35) View Subject | View Object

Appears in Networks:

Out-Edges 3

p(HGNC:VPS35) hasVariant p(HGNC:VPS35, var("?")) View Subject | View Object

Appears in Networks:

p(HGNC:VPS35) regulates act(p(HGNC:TREM2)) View Subject | View Object

VPS35, one of the retromer-related genes identified from GWAS datasets on AD [110], regulates TREM2’s function in microglia [111]. PubMed:29758300

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell

p(HGNC:VPS35) directlyIncreases complex(p(HGNC:SORL1), p(HGNC:VPS35)) View Subject | View Object

One intriguing molecule that interacts with VPS35 is SORL1, a VPS10P-domain receptor protein that has been linked to autosomal dominant early-onset AD [116,117]. PubMed:29758300

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.