a(HP:"Argyrophilic inclusion bodies")
Only proaggregant Tau transgenic slices reveal Taupositive beaded structures in the neuropil oriented mostly perpendicular to the apical dendrites of the CA1 pyramidal cells (Fig. 1 C and D, arrowheads) resembling grains in human AGD (16) PubMed:27671637
This suggests that proaggregant Tau accumulates in the axons as grains PubMed:27671637
Only proaggregant Tau transgenic slices reveal Taupositive beaded structures in the neuropil oriented mostly perpendicular to the apical dendrites of the CA1 pyramidal cells (Fig. 1 C and D, arrowheads) resembling grains in human AGD (16) PubMed:27671637
This suggests that proaggregant Tau accumulates in the axons as grains PubMed:27671637
Furthermore, we did not see colocalization of the grains of Tau and presynaptic marker synaptophysin (Fig. S3) PubMed:27671637
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.