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a(HBP:HBP00023)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HBP00023
Namespace
HBP
Namespace Version
20181029
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/785431732a26d6809b4162d98b95687d16404e63/export/hbp.belns

Appears in Networks 1

Amyloid β oligomers (AβOs) in Alzheimer’s disease v1.0.0

In-Edges 0

Out-Edges 3

a(HBP:HBP00023) increases a(CHEBI:"calcium(2+)") View Subject | View Object

It was demonstrated that Aβ42 oligomers, but not monomers, significantly altered Ca2+ release from intracellular stores (Lazzari et al. 2015), what induced intracellular Ca2+ increase in neurons via the complex PrPC–mGluR5, with harmful effects on synaptic transmission (Beraldo et al. 2016). PubMed:29196815

Appears in Networks:
Annotations
MeSH
Extracellular Space
Cell Ontology (CL)
neuron
Confidence
High
MeSH
Hippocampus

a(HBP:HBP00023) increases complex(p(HGNC:GRIK1), p(HGNC:PRNP)) View Subject | View Object

It was demonstrated that Aβ42 oligomers, but not monomers, significantly altered Ca2+ release from intracellular stores (Lazzari et al. 2015), what induced intracellular Ca2+ increase in neurons via the complex PrPC–mGluR5, with harmful effects on synaptic transmission (Beraldo et al. 2016). PubMed:29196815

Appears in Networks:
Annotations
MeSH
Extracellular Space
Cell Ontology (CL)
neuron
Confidence
High
MeSH
Hippocampus

a(HBP:HBP00023) decreases bp(GO:"signal release from synapse") View Subject | View Object

It was demonstrated that Aβ42 oligomers, but not monomers, significantly altered Ca2+ release from intracellular stores (Lazzari et al. 2015), what induced intracellular Ca2+ increase in neurons via the complex PrPC–mGluR5, with harmful effects on synaptic transmission (Beraldo et al. 2016). PubMed:29196815

Appears in Networks:
Annotations
MeSH
Extracellular Space
Cell Ontology (CL)
neuron
Confidence
High
MeSH
Hippocampus

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.