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complex(a(CHEBI:"lead(2+)"), a(CHEBI:thiol))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 0

Out-Edges 3

complex(a(CHEBI:"lead(2+)"), a(CHEBI:thiol)) hasComponent a(CHEBI:"lead(2+)") View Subject | View Object

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complex(a(CHEBI:"lead(2+)"), a(CHEBI:thiol)) hasComponent a(CHEBI:thiol) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"lead(2+)"), a(CHEBI:thiol)) decreases p(HGNC:ALAD) View Subject | View Object

For example, the binding of Pb2+ to protein sulfydryl groups would result in inhibition of ALA-D activity, leading to heme deficiency, and reduction of heme supply is a known reason for lead-related pathology.10,11 PubMed:25411909

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Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.