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a(CHEBI:"lead(2+)")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
lead(2+)
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

complex(a(CHEBI:"lead(2+)"), a(CHEBI:thiol)) hasComponent a(CHEBI:"lead(2+)") View Subject | View Object

Appears in Networks:

Out-Edges 2

a(CHEBI:"lead(2+)") decreases bp(GO:"erythrocyte differentiation") View Subject | View Object

These results suggest that Pb elicits direct inhibition of erythroid cell differentiation and that more importantly Hri takes a crucial role in promoting erythroid differentiation in response to Pb-induced toxicity. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

a(CHEBI:"lead(2+)") decreases bp(GO:"erythrocyte enucleation") View Subject | View Object

These data together demonstrated that Pb caused the inhibition of erythroid enucleation and that Hri seemingly surveilled the terminal differentiation of erythroblasts for appropriate hemoglobin production and final maturation before enucleation. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.