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p(HGNC:MAPT, frag("561_685"))

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Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

In-Edges 3

act(a(CHEBI:Thrombin)) causesNoChange p(HGNC:MAPT, frag("561_685")) View Subject | View Object

Evidence supporting a role for thrombin in tau proteolysis came initially from an in vitro study showing that thrombin degraded recombinant full-length tau from the N-terminus yielding a 25-kDa fragment, while preserving the microtubule binding repeat domain (13). PubMed:24027553

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Text Location
Review

act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT, frag("561_685"))) View Subject | View Object

A later study, however, showed that in N2a neuroblastoma cells expressing a construct of only the tau repeat domain, thrombin cleavage could still occur, indicating additional cleavage sites (15). Similar results were observed in an in vitro assay (15). PubMed:24027553

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Text Location
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p(HGNC:MAPT) hasVariant p(HGNC:MAPT, frag("561_685")) View Subject | View Object

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Out-Edges 2

deg(p(HGNC:MAPT, frag("561_685"))) increases a(HBP:"Tau aggregates") View Subject | View Object

Thrombin cleavage of the repeat domain construct yielded fragments that rapidly aggregated, which closely correlated with toxicity in cell culture (15). These fragments can also induce the aggregation of full-length tau (39). PubMed:24027553

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Review

p(HGNC:MAPT, frag("561_685")) increases a(HBP:"Tau aggregates") View Subject | View Object

Overexpressing only the repeat domain of tau containing an FTDP-17 mutation in neuroblastoma cells leads to tau aggregation as well as the appearance of smaller proteolytic fragments. Using the autophagy inhibitor 3-methyladenine (3-MA) to block the formation of autophagosomes led to an increase in both soluble and insoluble tau (94). PubMed:24027553

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MeSH
Frontotemporal Dementia
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.