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Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

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a(CHEBI:"lead nitrate") increases g(MGI:Ly76) View Subject | View Object

In stark contrast to Wt mice, there was an exuberant increase (57.9%) in Ter119+ cells in Ko + Pb mice, compared to that in Ko − Pb mice (Figure 3A; P = 0.01), suggesting enhanced medullary erythropoiesis in Ko mice upon Pb(NO3)2 administration. PubMed:25411909

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Serum
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a(CHEBI:"lead nitrate") increases g(MGI:Ly76) View Subject | View Object

As shown in Figure 4B, Pb treatment resulted in an induction of splenic Ter119+ erythroid cells in Ko + Pb mice, compared to that in Wt + Pb mice (59.6% vs 36.5%, P < 0.001; Figure 4B). PubMed:25411909

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Cell Ontology (CL)
erythroid progenitor cell
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Spleen
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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.