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a(CHEBI:"lead nitrate")

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Entity

Name
lead nitrate
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 13

a(CHEBI:"iron(2+)") positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

With respect to the absence of Hri, there were slightly greater serum iron concentrations, total splenic iron content, and hepatic hepcidin expression level in Hri-deficient mice, relative to those in Wt mice (Figure 8A−C). PubMed:25411909

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Cell Ontology (CL)
erythroid progenitor cell
MeSH
Serum
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a(CHEBI:"iron(2+)") positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

However, Pb exposure induced hepatic hepcidin expression by nearly 2- fold in Ko + Pb mice with a resultant significant increase of total splenic iron, compared to that in Ko − Pb mice (Figure 8 B and C; P < 0.05). PubMed:25411909

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Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

a(MESH:Erythroblasts) positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

Consistent with the FACS analysis results, abundant production of erythroblast and megakaryocytes in the sections of BM from Ko + Pb mice was observed, indicting enhanced medullary erythropoiesis (Figure 3C). PubMed:25411909

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MeSH
Bone Marrow
Text Location
Results

a(MESH:Erythroblasts) positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

Examination of histological sections of spleens showed a dramatic expansion of erythroblasts in the red pulp of the spleens of Hri-null mice upon Pb administration (Figure 4C). PubMed:25411909

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Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

a(MESH:Megakaryocytes) positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

Consistent with the FACS analysis results, abundant production of erythroblast and megakaryocytes in the sections of BM from Ko + Pb mice was observed, indicting enhanced medullary erythropoiesis (Figure 3C). PubMed:25411909

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MeSH
Bone Marrow
Text Location
Results

bp(GO:"erythrocyte apoptotic process") positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

In Ko + Pb mice, apoptotic cells were increased by a greater degree, 79.4% in BM erythrocytes, compared to those in Ko − Pb mice (Figure 7B; P = 0.012). PubMed:25411909

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Cell Ontology (CL)
erythroid progenitor cell
MeSH
Bone Marrow
Text Location
Results

bp(GO:"erythrocyte apoptotic process") positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

Apoptosis of splenic erythrocytes in Ko + Pb mice was enhanced by 19.0%, compared to that in Ko − Pb mice and by 55.4% in comparison to that in Wt + Pb mice (Figure 7C; P = 0.019). PubMed:25411909

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Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

bp(GO:"erythrocyte differentiation") negativeCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

These results also indicated that, in spite of enforced extramedullary and medullary erythropoiesis in Ko + Pb mice, erythroid cells did not robustly survive and differentiate under Pb exposure as shown in Table 1, analogous to the observations in cadmium-treated mice.22 PubMed:25411909

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Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

bp(MESH:Erythropoiesis) positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

In stark contrast to Wt mice, there was an exuberant increase (57.9%) in Ter119+ cells in Ko + Pb mice, compared to that in Ko − Pb mice (Figure 3A; P = 0.01), suggesting enhanced medullary erythropoiesis in Ko mice upon Pb(NO3)2 administration. PubMed:25411909

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p(MGI:Hamp) positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

With respect to the absence of Hri, there were slightly greater serum iron concentrations, total splenic iron content, and hepatic hepcidin expression level in Hri-deficient mice, relative to those in Wt mice (Figure 8A−C). PubMed:25411909

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Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Liver
Text Location
Results

p(MGI:Hamp) positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

However, Pb exposure induced hepatic hepcidin expression by nearly 2- fold in Ko + Pb mice with a resultant significant increase of total splenic iron, compared to that in Ko − Pb mice (Figure 8 B and C; P < 0.05). PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Liver
Text Location
Results

path(MESH:"Hematopoiesis, Extramedullary") positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

Extramedullary and medullary erythropoiesis was enhanced in Hri-null mice upon Pb treatment. PubMed:25411909

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Cell Ontology (CL)
erythrocyte
MeSH
Spleen
Text Location
Discussion

path(MESH:Anemia) positiveCorrelation a(CHEBI:"lead nitrate") View Subject | View Object

In contrast, Ko mice administrated with Pb(NO3)2 (Ko + Pb) developed significant anemia, evidenced by a great reduction of RBC count and hemoglobin concentration, compared to those of untreated Hri Ko mice (Ko − Pb) and Wt + Pb mice (Table 1; P < 0.05). PubMed:25411909

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Out-Edges 20

a(CHEBI:"lead nitrate") positiveCorrelation path(MESH:Anemia) View Subject | View Object

In contrast, Ko mice administrated with Pb(NO3)2 (Ko + Pb) developed significant anemia, evidenced by a great reduction of RBC count and hemoglobin concentration, compared to those of untreated Hri Ko mice (Ko − Pb) and Wt + Pb mice (Table 1; P < 0.05). PubMed:25411909

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a(CHEBI:"lead nitrate") increases a(MESH:Reticulocytes) View Subject | View Object

Analogous to phenotypic observations of anemia, the percentage of reticulocytes in peripheral blood of Ko + Pb mice was greatly induced by more than 2-fold relative to Ko − Pb mice (P < 0.05) and Wt + Pb mice (P < 0.001) (Figure 2A and B). PubMed:25411909

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a(CHEBI:"lead nitrate") increases a(CHEBI:bilirubin) View Subject | View Object

The serum levels of direct bilirubin (DBil) and total bilirubin (TBil) were significantly increased in Ko + Pb mice, compared to those in Ko − Pb mice and Wt + Pb mice (Figure 2C and D; P < 0.05). PubMed:25411909

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Serum
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Results

a(CHEBI:"lead nitrate") decreases bp(MESH:Hematocrit) View Subject | View Object

Furthermore, the level of hematocrit (HCT) was also diminished by roughly 15% in Ko + Pb mice, compared to that in Wt + Pb mice (Table 1), and the mean corpuscular volume (MCV) in Ko + Pb mice was elevated by approximately 15% and 21%, compared to that in Ko − Pb mice and Wt + Pb mice, respectively (Table 1; P < 0.05). PubMed:25411909

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Serum
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Results

a(CHEBI:"lead nitrate") increases bp(MESH:"Erythrocyte Volume") View Subject | View Object

Furthermore, the level of hematocrit (HCT) was also diminished by roughly 15% in Ko + Pb mice, compared to that in Wt + Pb mice (Table 1), and the mean corpuscular volume (MCV) in Ko + Pb mice was elevated by approximately 15% and 21%, compared to that in Ko − Pb mice and Wt + Pb mice, respectively (Table 1; P < 0.05). PubMed:25411909

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MeSH
Serum
Text Location
Results

a(CHEBI:"lead nitrate") increases g(MGI:Ly76) View Subject | View Object

In stark contrast to Wt mice, there was an exuberant increase (57.9%) in Ter119+ cells in Ko + Pb mice, compared to that in Ko − Pb mice (Figure 3A; P = 0.01), suggesting enhanced medullary erythropoiesis in Ko mice upon Pb(NO3)2 administration. PubMed:25411909

Appears in Networks:
Annotations
MeSH
Serum
Text Location
Results

a(CHEBI:"lead nitrate") increases g(MGI:Ly76) View Subject | View Object

As shown in Figure 4B, Pb treatment resulted in an induction of splenic Ter119+ erythroid cells in Ko + Pb mice, compared to that in Wt + Pb mice (59.6% vs 36.5%, P < 0.001; Figure 4B). PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

a(CHEBI:"lead nitrate") positiveCorrelation bp(MESH:Erythropoiesis) View Subject | View Object

In stark contrast to Wt mice, there was an exuberant increase (57.9%) in Ter119+ cells in Ko + Pb mice, compared to that in Ko − Pb mice (Figure 3A; P = 0.01), suggesting enhanced medullary erythropoiesis in Ko mice upon Pb(NO3)2 administration. PubMed:25411909

Appears in Networks:
Annotations
MeSH
Serum
Text Location
Results

a(CHEBI:"lead nitrate") positiveCorrelation a(MESH:Erythroblasts) View Subject | View Object

Consistent with the FACS analysis results, abundant production of erythroblast and megakaryocytes in the sections of BM from Ko + Pb mice was observed, indicting enhanced medullary erythropoiesis (Figure 3C). PubMed:25411909

Appears in Networks:
Annotations
MeSH
Bone Marrow
Text Location
Results

a(CHEBI:"lead nitrate") positiveCorrelation a(MESH:Erythroblasts) View Subject | View Object

Examination of histological sections of spleens showed a dramatic expansion of erythroblasts in the red pulp of the spleens of Hri-null mice upon Pb administration (Figure 4C). PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

a(CHEBI:"lead nitrate") positiveCorrelation a(MESH:Megakaryocytes) View Subject | View Object

Consistent with the FACS analysis results, abundant production of erythroblast and megakaryocytes in the sections of BM from Ko + Pb mice was observed, indicting enhanced medullary erythropoiesis (Figure 3C). PubMed:25411909

Appears in Networks:
Annotations
MeSH
Bone Marrow
Text Location
Results

a(CHEBI:"lead nitrate") negativeCorrelation bp(GO:"erythrocyte differentiation") View Subject | View Object

These results also indicated that, in spite of enforced extramedullary and medullary erythropoiesis in Ko + Pb mice, erythroid cells did not robustly survive and differentiate under Pb exposure as shown in Table 1, analogous to the observations in cadmium-treated mice.22 PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

a(CHEBI:"lead nitrate") decreases a(CHEBI:heme) View Subject | View Object

Pb treatment has been demonstrated to reduce heme availability for globin assembly.38 PubMed:25411909

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Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

a(CHEBI:"lead nitrate") positiveCorrelation bp(GO:"erythrocyte apoptotic process") View Subject | View Object

In Ko + Pb mice, apoptotic cells were increased by a greater degree, 79.4% in BM erythrocytes, compared to those in Ko − Pb mice (Figure 7B; P = 0.012). PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Bone Marrow
Text Location
Results

a(CHEBI:"lead nitrate") positiveCorrelation bp(GO:"erythrocyte apoptotic process") View Subject | View Object

Apoptosis of splenic erythrocytes in Ko + Pb mice was enhanced by 19.0%, compared to that in Ko − Pb mice and by 55.4% in comparison to that in Wt + Pb mice (Figure 7C; P = 0.019). PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

a(CHEBI:"lead nitrate") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

With respect to the absence of Hri, there were slightly greater serum iron concentrations, total splenic iron content, and hepatic hepcidin expression level in Hri-deficient mice, relative to those in Wt mice (Figure 8A−C). PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Serum
Text Location
Results

a(CHEBI:"lead nitrate") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

However, Pb exposure induced hepatic hepcidin expression by nearly 2- fold in Ko + Pb mice with a resultant significant increase of total splenic iron, compared to that in Ko − Pb mice (Figure 8 B and C; P < 0.05). PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Spleen
Text Location
Results

a(CHEBI:"lead nitrate") positiveCorrelation p(MGI:Hamp) View Subject | View Object

With respect to the absence of Hri, there were slightly greater serum iron concentrations, total splenic iron content, and hepatic hepcidin expression level in Hri-deficient mice, relative to those in Wt mice (Figure 8A−C). PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Liver
Text Location
Results

a(CHEBI:"lead nitrate") positiveCorrelation p(MGI:Hamp) View Subject | View Object

However, Pb exposure induced hepatic hepcidin expression by nearly 2- fold in Ko + Pb mice with a resultant significant increase of total splenic iron, compared to that in Ko − Pb mice (Figure 8 B and C; P < 0.05). PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythroid progenitor cell
MeSH
Liver
Text Location
Results

a(CHEBI:"lead nitrate") positiveCorrelation path(MESH:"Hematopoiesis, Extramedullary") View Subject | View Object

Extramedullary and medullary erythropoiesis was enhanced in Hri-null mice upon Pb treatment. PubMed:25411909

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Spleen
Text Location
Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.