path(MESH:Anemia)
In contrast, Ko mice administrated with Pb(NO3)2 (Ko + Pb) developed significant anemia, evidenced by a great reduction of RBC count and hemoglobin concentration, compared to those of untreated Hri Ko mice (Ko − Pb) and Wt + Pb mice (Table 1; P < 0.05). PubMed:25411909
Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418
Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418
Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418
The anemia in CEP mice was severe with significant reduction of Hb levels and RBC number (Table 1), regenerative with marked reticulocytosis (28.8±4.2%) (Table 1), and microcytic and hypochromic with reduced mean cell Hb content (9.95±0.64 pg in CEP vs. 14.5±0.18 in WT mice) (Table 1). PubMed:28143953
On the other hand, eryptosis is associated with anemia, microcirculatory derangement, and thrombosis [142, 144]. PubMed:29956069
The anemia in CEP mice was severe with significant reduction of Hb levels and RBC number (Table 1), regenerative with marked reticulocytosis (28.8±4.2%) (Table 1), and microcytic and hypochromic with reduced mean cell Hb content (9.95±0.64 pg in CEP vs. 14.5±0.18 in WT mice) (Table 1). PubMed:28143953
Under Pb administration, Wt mice did not develop phenotypes of anemia; however, Hri-deficient mice developed severe anemia. PubMed:25411909
Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418
Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418
Surprisingly, even moderate levels of preoperative anemia [hemoglobin (Hb) concentrations between 80 and 100 g/l] have been associated with an increased risk of renal injury {odds ratio (OR): 1.38 [95% confidence interval (CI) 1.18 –1.62], P 0.05} (28). PubMed:29351418
In perioperative medicine, there is a clear association between preoperative anemia and AKI in noncardiac and cardiac surgery (17, 18, 20, 28). PubMed:29351418
Extramedullary erythropoiesis is often switched on upon anemia, as characterized by splenomegaly.31 PubMed:25411909
Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418
Under Pb administration, Wt mice did not develop phenotypes of anemia; however, Hri-deficient mice developed severe anemia. PubMed:25411909
In contrast, Ko mice administrated with Pb(NO3)2 (Ko + Pb) developed significant anemia, evidenced by a great reduction of RBC count and hemoglobin concentration, compared to those of untreated Hri Ko mice (Ko − Pb) and Wt + Pb mice (Table 1; P < 0.05). PubMed:25411909
Extramedullary erythropoiesis is often switched on upon anemia, as characterized by splenomegaly.31 PubMed:25411909
The anemia in CEP mice was severe with significant reduction of Hb levels and RBC number (Table 1), regenerative with marked reticulocytosis (28.8±4.2%) (Table 1), and microcytic and hypochromic with reduced mean cell Hb content (9.95±0.64 pg in CEP vs. 14.5±0.18 in WT mice) (Table 1). PubMed:28143953
By day 1 following injection, plasma Hb concentrations in the anemia group were reduced to 0.5 0.3 g/l, which was not significantly different from the control value of 0.5 0.3 g/l (n 6, unadjusted P 0.93; Fig. 3A). PubMed:29351418
The anemia in CEP mice was severe with significant reduction of Hb levels and RBC number (Table 1), regenerative with marked reticulocytosis (28.8±4.2%) (Table 1), and microcytic and hypochromic with reduced mean cell Hb content (9.95±0.64 pg in CEP vs. 14.5±0.18 in WT mice) (Table 1). PubMed:28143953
Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418
Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418
Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418
Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418
Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418
Surprisingly, even moderate levels of preoperative anemia [hemoglobin (Hb) concentrations between 80 and 100 g/l] have been associated with an increased risk of renal injury {odds ratio (OR): 1.38 [95% confidence interval (CI) 1.18 –1.62], P 0.05} (28). PubMed:29351418
In perioperative medicine, there is a clear association between preoperative anemia and AKI in noncardiac and cardiac surgery (17, 18, 20, 28). PubMed:29351418
Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418
SpO2 values increased in anemic mice (n 6) from a baseline value of 97.1 0.6% to a day 3 value of 98.1 0.2 and a day 4 value of 97.8 0.4% (n 6, unadjusted P 0.02, adjusted P 0.05; Fig. 4). Day 4 SpO2 values were higher than a control value of 97.0 0.8% (n 6; unadjusted P 0.01, adjusted P 0.05). PubMed:29351418
Internal carotid artery flow increased from a baseline value of 0.3 0.1 ml/min to 0.6 0.1 ml/min during anemia (unadjusted P 0.001, adjusted P 0.001; Fig. 5). PubMed:29351418
During anemia, kidney PtO2 was reduced to a value of 13.1 4.3 mmHg (n 10) compared with a control value of 20.8 3.7 mmHg (n 14; P 0.001; Fig. 6). PubMed:29351418
Brain PtO2 of anemic mice was 22.7 5.2 mmHg (n 13), which was not significantly different from a control value of 23.4 9.8 mmHg (n 14, P 0.59). PubMed:29351418
D). “Right kidney liver region” HIF/luciferase radiance increased from a baseline value of 5.30 107 1.23 107 p/s to a day 4 value of 6.72 107 1.63 107 p/s (unadjusted P 0.01, adjusted P 0.04; Fig. 7E). PubMed:29351418
“Gut region” HIF/luciferase radiance at the day 4 time point was 4.38 108 4.00 108 p/s, which was higher than a control value of 2.36 108 0.93 108 p/s (unadjusted P 0.001, adjusted P 0.001; Fig. 8E). PubMed:29351418
In addition, change in day 4 gut region HIF/luciferase radiance values from baseline in anemic mice was 1.68 108 3.48 108 p/s, which was higher than a control value of 1.08 108 1.28 108 p/s (P 0.02). PubMed:29351418
During anemia (n 6), kidney EPO mRNA transcription increased 20-fold relative to control mice (n 5, P 0.001; Fig. 9A). PubMed:29351418
Heart EPO mRNA transcription was not significantly different in anemic mice relative to control mice (P 0.35). PubMed:29351418
Despite the preserved tissue PO2 level during subacute anemia, we demonstrated an increase in HIF-dependent mRNA levels of EPO, HO-1, and GAPDH. This finding is consistent with other experimental studies that have also demonstrated increases in HIF-dependent mRNA expression in the absence of a clear reduction in brain PtO2 (12, 23). PubMed:29351418
Brain HO-1 mRNA levels increased by 38% in anemic mice relative to control mice (P 0.01), and GAPDH mRNA levels increased by 18% in anemic mice relative to control mice (P 0.002; Fig. 9B). PubMed:29351418
Despite the preserved tissue PO2 level during subacute anemia, we demonstrated an increase in HIF-dependent mRNA levels of EPO, HO-1, and GAPDH. This finding is consistent with other experimental studies that have also demonstrated increases in HIF-dependent mRNA expression in the absence of a clear reduction in brain PtO2 (12, 23). PubMed:29351418
Brain HO-1 mRNA levels increased by 38% in anemic mice relative to control mice (P 0.01), and GAPDH mRNA levels increased by 18% in anemic mice relative to control mice (P 0.002; Fig. 9B). PubMed:29351418
Despite the preserved tissue PO2 level during subacute anemia, we demonstrated an increase in HIF-dependent mRNA levels of EPO, HO-1, and GAPDH. This finding is consistent with other experimental studies that have also demonstrated increases in HIF-dependent mRNA expression in the absence of a clear reduction in brain PtO2 (12, 23). PubMed:29351418
Our experimental data provided clear evidence that moderate subacute anemia resulted in a profound level of renal tissue hypoxia, as characterized by a reduction in kidney PtO2, an increase in regional HIF/luciferase radiance in vivo, and a substantial increase in EPO mRNA level at a Hb concentration consistent with moderate anemia (90 g/l). PubMed:29351418
On the other hand, eryptosis is associated with anemia, microcirculatory derangement, and thrombosis [142, 144]. PubMed:29956069
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.