path(MESH:Stroke)
Although RBC transfusions reduce the risk of stroke in SCD (Adams et al, 1998), both clinical strokes and silent infarcts still occur. PubMed:25307023
Nonfunctioning CD59 is a major risk factor for stroke and hypercoagulability. PubMed:29929138
More recently, we have described two infants carrying the mutation who manifested with recurrent strokes [8], establishing the concept that primary Cys89Tyr mutation in CD59 leads to a thrombophilic state. PubMed:29929138
We recently encountered patients with recurrent strokes leading to premature death in 2/7 young children with primary Cys89Tyr CD59 deficiency [8]. PubMed:29929138
Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418
Furthermore, postmortem brain tissues from stroke patients show increase protein levels of inflammasomes in primary cortical neurons (Yang- Wei Fann et al., 2013) PubMed:24561250
Although RBC transfusions reduce the risk of stroke in SCD (Adams et al, 1998), both clinical strokes and silent infarcts still occur. PubMed:25307023
Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418
More recently, we have described two infants carrying the mutation who manifested with recurrent strokes [8], establishing the concept that primary Cys89Tyr mutation in CD59 leads to a thrombophilic state. PubMed:29929138
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.