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r(MGI:Hmox1)

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Entity

Name
Hmox1
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

p(MGI:Hpx) decreases r(MGI:Hmox1) View Subject | View Object

Consistently, HO-1 mRNA and protein levels were higher in hearts from Hx-/- mice than in controls (Figure 2B). Immunohistochemistry for HO-1 on heart sections indicated higher HO-1 expression in cardiomyocytes from Hx-/- mice than in wild-type animals (Figure 2B). PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
regular cardiac myocyte
Text Location
Results

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation r(MGI:Hmox1) View Subject | View Object

Interestingly, the mRNA expression levels of HO-1 and ferroportin, which are both induced transcriptionally by free heme, were enhanced significantly in the cortex, but not in the medulla, of CEP mice, resulting in large increases in their protein abundance (Figure 6). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

path(MESH:Anemia) increases r(MGI:Hmox1) View Subject | View Object

Brain HO-1 mRNA levels increased by 38% in anemic mice relative to control mice (P  0.01), and GAPDH mRNA levels increased by 18% in anemic mice relative to control mice (P  0.002; Fig. 9B). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Brain
Text Location
Results

path(MESH:Anemia) increases r(MGI:Hmox1) View Subject | View Object

Despite the preserved tissue PO2 level during subacute anemia, we demonstrated an increase in HIF-dependent mRNA levels of EPO, HO-1, and GAPDH. This finding is consistent with other experimental studies that have also demonstrated increases in HIF-dependent mRNA expression in the absence of a clear reduction in brain PtO2 (12, 23). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Anemia
Text Location
Discussion

Out-Edges 1

r(MGI:Hmox1) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Interestingly, the mRNA expression levels of HO-1 and ferroportin, which are both induced transcriptionally by free heme, were enhanced significantly in the cortex, but not in the medulla, of CEP mice, resulting in large increases in their protein abundance (Figure 6). PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
inner renal cortex cell
MeSH
Kidney Cortex
MeSH
Porphyria, Erythropoietic
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.