path(MESH:"Acute Kidney Injury")
Heme may be implicated and contribute to the development of (i) bp(MESH: PubMed:26875449
By binding cell-free hemoglobin, haptoglobin prevents glomerular filtration of cell-free hemoglobin and subsequent kidney injury (2,7). PubMed:28314763
For instance, Hmox−/− mice develops acute renal failure and marked mortality when submitted to rhabdomyolysis, a pathological condition that increases serum myoglobin which can be oxidized and release heme (Nath et al., 2000). PubMed:24904418
Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418
Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418
Surprisingly, even moderate levels of preoperative anemia [hemoglobin (Hb) concentrations between 80 and 100 g/l] have been associated with an increased risk of renal injury {odds ratio (OR): 1.38 [95% confidence interval (CI) 1.18 –1.62], P 0.05} (28). PubMed:29351418
In perioperative medicine, there is a clear association between preoperative anemia and AKI in noncardiac and cardiac surgery (17, 18, 20, 28). PubMed:29351418
Renal damage has also been reported to occur throughout many other acute hemolytic conditions associated with hemoglobinuria. PubMed:26794659
Therefore, acute kidney injury (AKI) remains an important complication of acute and severe intravascular hemolysis. PubMed:26794659
For instance, Hmox−/− mice develops acute renal failure and marked mortality when submitted to rhabdomyolysis, a pathological condition that increases serum myoglobin which can be oxidized and release heme (Nath et al., 2000). PubMed:24904418
Therefore, acute kidney injury (AKI) remains an important complication of acute and severe intravascular hemolysis. PubMed:26794659
Renal damage has also been reported to occur throughout many other acute hemolytic conditions associated with hemoglobinuria. PubMed:26794659
Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. PubMed:29351418
Anemia has been associated with an increased risk of acute kidney injury (AKI) (17, 18, 20, 27, 28), stroke (17, 20, 27), myocardial events (6, 11, 20, 28, 47), and mortality (1, 2, 10, 11, 17, 20, 27, 28, 36, 45, 47) in patients undergoing surgery. PubMed:29351418
Surprisingly, even moderate levels of preoperative anemia [hemoglobin (Hb) concentrations between 80 and 100 g/l] have been associated with an increased risk of renal injury {odds ratio (OR): 1.38 [95% confidence interval (CI) 1.18 –1.62], P 0.05} (28). PubMed:29351418
In perioperative medicine, there is a clear association between preoperative anemia and AKI in noncardiac and cardiac surgery (17, 18, 20, 28). PubMed:29351418
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.