1. Catalog
  2. Nodes
  3. path(MESH:Hemoglobinuria)

path(MESH:Hemoglobinuria)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Hemoglobinuria
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 10

a(MESH:"Blood Transfusion") positiveCorrelation path(MESH:Hemoglobinuria) View Subject | View Object

Isovolemic transfusion of guinea pigs with 10-unit equivalents of old blood, which consisted of red blood cells that were stored for 28 days, led to moderate hemoglobinuria. PubMed:26794659

Appears in Networks:
Annotations
MeSH
Liver
Text Location
Results

a(MESH:"Blood Transfusion") positiveCorrelation path(MESH:Hemoglobinuria) View Subject | View Object

Hemoglobinuria was noted in mice resuscitated with SRBCs alone but not mice resuscitated with FRBCs or sham-treated mice (Figure 4A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

p(MGI:Hpx) increases path(MESH:Hemoglobinuria) View Subject | View Object

These results show that, in contrast to haptoglobin, hemopexin 247 was unable to prevent free hemoglobin-induced hemoglobinuria. PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation path(MESH:Hemoglobinuria) View Subject | View Object

Hemoglobinuria was present in mice resuscitated with SRBCs combined with albumin or hemopexin but not in mice resuscitated with SRBCs combined with haptoglobin (Figure 4A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation path(MESH:Hemoglobinuria) View Subject | View Object

Co-infusion of haptoglobin but not albumin or hemopexin prevented SRBC-induced hemoglobinuria and kidney injury at 48 hours after resuscitation from hemorrhagic shock. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

p(MGI:Hp) decreases path(MESH:Hemoglobinuria) View Subject | View Object

Furthermore, haptoglobin retained cell-free 338 hemoglobin in plasma and prevented hemoglobinuria. PubMed:28314763

Appears in Networks:
Annotations
MeSH
Diabetes Mellitus
Text Location
Introduction

p(MGI:Hp) decreases path(MESH:Hemoglobinuria) View Subject | View Object

In mice fed a HFD or in 339 diabetic mice fed a normal diet, haptoglobin mixed with murine tetrameric 340 hemoglobin in a 1:1 weight ratio also retained cell-free hemoglobin in plasma and 341 prevented hemoglobinuria but did not reduce hemoglobin-induced hypertension. PubMed:28314763

Appears in Networks:
Annotations
MeSH
Diabetes Mellitus
Text Location
Introduction

p(MGI:Hp) decreases path(MESH:Hemoglobinuria) View Subject | View Object

In the 358 current study, we demonstrated that administration of human haptoglobin retained 359 cell-free hemoglobin in plasma, prevented hemoglobinuria, and reduced the 360 hemoglobin-induced hypertension in healthy awake mice (see Figure 1A). PubMed:28314763

Appears in Networks:
Annotations
MeSH
Arteries
MeSH
Diabetes Mellitus
Text Location
Introduction

complex(p(HGNC:HBB), p(MGI:Hp)) decreases path(MESH:Hemoglobinuria) View Subject | View Object

Taken together these results suggest that infusion of cell-free hemoglobin 264 mixed with an equal mass of haptoglobin is sufficient to bind cell-free hemoglobin 265 and prevent renal clearance of extracellular hemoglobin. PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:"Acute Kidney Injury") association path(MESH:Hemoglobinuria) View Subject | View Object

Renal damage has also been reported to occur throughout many other acute hemolytic conditions associated with hemoglobinuria. PubMed:26794659

Appears in Networks:
Annotations
MeSH
Liver
Text Location
Introduction

Out-Edges 5

path(MESH:Hemoglobinuria) association path(MESH:"Acute Kidney Injury") View Subject | View Object

Renal damage has also been reported to occur throughout many other acute hemolytic conditions associated with hemoglobinuria. PubMed:26794659

Appears in Networks:
Annotations
MeSH
Liver
Text Location
Introduction

path(MESH:Hemoglobinuria) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Isovolemic transfusion of guinea pigs with 10-unit equivalents of old blood, which consisted of red blood cells that were stored for 28 days, led to moderate hemoglobinuria. PubMed:26794659

Appears in Networks:
Annotations
MeSH
Liver
Text Location
Results

path(MESH:Hemoglobinuria) positiveCorrelation a(MESH:"Blood Transfusion") View Subject | View Object

Hemoglobinuria was noted in mice resuscitated with SRBCs alone but not mice resuscitated with FRBCs or sham-treated mice (Figure 4A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

path(MESH:Hemoglobinuria) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

Hemoglobinuria was present in mice resuscitated with SRBCs combined with albumin or hemopexin but not in mice resuscitated with SRBCs combined with haptoglobin (Figure 4A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

path(MESH:Hemoglobinuria) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

Co-infusion of haptoglobin but not albumin or hemopexin prevented SRBC-induced hemoglobinuria and kidney injury at 48 hours after resuscitation from hemorrhagic shock. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.