1. Catalog
  2. Nodes
  3. complex(p(HGNC:HBB), p(MGI:Hp))

complex(p(HGNC:HBB), p(MGI:Hp))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 0

Out-Edges 7

complex(p(HGNC:HBB), p(MGI:Hp)) hasComponent p(HGNC:HBB) View Subject | View Object

Appears in Networks:

complex(p(HGNC:HBB), p(MGI:Hp)) hasComponent p(MGI:Hp) View Subject | View Object

Appears in Networks:

complex(p(HGNC:HBB), p(MGI:Hp)) decreases bp(MESH:"Blood Pressure") View Subject | View Object

Co-administration of haptoglobin attenuated the hemoglobin-induced increase in SBP during the 40 minutes after co-injection by an average of 13±3 mmHg (Figure 1A). PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

complex(p(HGNC:HBB), p(MGI:Hp)) decreases path(MESH:Hypertension) View Subject | View Object

These results 230 suggest that co-injection of haptoglobin but not hemopexin with cell-free hemoglobin 231 can prevent hemoglobin-induced hypertension in awake, healthy mice. PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

complex(p(HGNC:HBB), p(MGI:Hp)) decreases bp(MESH:"Glomerular Filtration Rate") View Subject | View Object

Haptoglobin binds to cell-free hemoglobin and thereby prevents glomerular filtration 237 (6). PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

complex(p(HGNC:HBB), p(MGI:Hp)) increases a(HM:"nitric oxide consumption") View Subject | View Object

Mice that received cell free hemoglobin together with haptoglobin had significantly higher plasma NO 258 consumption than mice that received cell-free hemoglobin alone at 60 minutes after 259 injection. PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

complex(p(HGNC:HBB), p(MGI:Hp)) decreases path(MESH:Hemoglobinuria) View Subject | View Object

Taken together these results suggest that infusion of cell-free hemoglobin 264 mixed with an equal mass of haptoglobin is sufficient to bind cell-free hemoglobin 265 and prevent renal clearance of extracellular hemoglobin. PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.