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In-Edges 7

p(HGNC:ACE) regulates bp(MESH:"Blood Pressure") View Subject | View Object

ACE, a membrane-bound zinc metalloprotease, catalyzes the transformation of angiotensin I to angiotensin II, which is beneficial to the maintenance of body fluid, blood pressure, and sodium balance PubMed:29626319

p(HGNC:HBB) increases bp(MESH:"Blood Pressure") View Subject | View Object

Presence of any cell-free Hb limits NO diffusion from endothelium to smooth muscle cells for activation of guanylyl cyclase; as a consequence, mean arterial blood pressure increases.12,15 PubMed:27308950

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Arteries
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p(HGNC:HBB) increases bp(MESH:"Blood Pressure") View Subject | View Object

SBP 315 increased 27±2 mmHg during the 40 minutes following infusion of hemoglobin in 316 db/db mice (Figure 4A). PubMed:28314763

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Diabetes Mellitus
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p(HGNC:HPX) negativeCorrelation bp(MESH:"Blood Pressure") View Subject | View Object

Correlation analysis using Pearson’s correlation coefficient showed statistically significant inverse correlation between Hpx and blood pressure, both systolic (r = -0.511, pvalue< 0.00001, n = 145) and diastolic (r = -0,520, p-value<0.00001, n = 145)(Fig 3). PubMed:26368565

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hepatocyte
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Plasma
MeSH
Pre-Eclampsia
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p(MGI:Hpx) decreases bp(MESH:"Blood Pressure") View Subject | View Object

In mouse models associated with 392 chronic hemolysis and heme overload, such as in mice with a sickle hemoglobin 393 (HbS) gene knock-in or mouse models of β-thalassemia, repeated treatment with 394 hemopexin was shown to reduce chronically elevated blood pressure (21). PubMed:28314763

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endothelial cell
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Arteries
MeSH
Diabetes Mellitus
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complex(p(HGNC:HBB), p(MGI:Hp)) decreases bp(MESH:"Blood Pressure") View Subject | View Object

Co-administration of haptoglobin attenuated the hemoglobin-induced increase in SBP during the 40 minutes after co-injection by an average of 13±3 mmHg (Figure 1A). PubMed:28314763

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complex(p(HGNC:HBB), p(MGI:Hpx)) increases bp(MESH:"Blood Pressure") View Subject | View Object

SBP increased 224 on average 20±2 mmHg in mice injected with hemoglobin mixed with hemopexin and 225 therefore was similar to the increase after hemoglobin injection alone. PubMed:28314763

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Out-Edges 1

bp(MESH:"Blood Pressure") negativeCorrelation p(HGNC:HPX) View Subject | View Object

Correlation analysis using Pearson’s correlation coefficient showed statistically significant inverse correlation between Hpx and blood pressure, both systolic (r = -0.511, pvalue< 0.00001, n = 145) and diastolic (r = -0,520, p-value<0.00001, n = 145)(Fig 3). PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Results

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.