bp(MESH:"Blood Pressure")
ACE, a membrane-bound zinc metalloprotease, catalyzes the transformation of angiotensin I to angiotensin II, which is beneficial to the maintenance of body fluid, blood pressure, and sodium balance PubMed:29626319
Presence of any cell-free Hb limits NO diffusion from endothelium to smooth muscle cells for activation of guanylyl cyclase; as a consequence, mean arterial blood pressure increases.12,15 PubMed:27308950
SBP 315 increased 27±2 mmHg during the 40 minutes following infusion of hemoglobin in 316 db/db mice (Figure 4A). PubMed:28314763
Correlation analysis using Pearson’s correlation coefficient showed statistically significant inverse correlation between Hpx and blood pressure, both systolic (r = -0.511, pvalue< 0.00001, n = 145) and diastolic (r = -0,520, p-value<0.00001, n = 145)(Fig 3). PubMed:26368565
In mouse models associated with 392 chronic hemolysis and heme overload, such as in mice with a sickle hemoglobin 393 (HbS) gene knock-in or mouse models of β-thalassemia, repeated treatment with 394 hemopexin was shown to reduce chronically elevated blood pressure (21). PubMed:28314763
Co-administration of haptoglobin attenuated the hemoglobin-induced increase in SBP during the 40 minutes after co-injection by an average of 13±3 mmHg (Figure 1A). PubMed:28314763
SBP increased 224 on average 20±2 mmHg in mice injected with hemoglobin mixed with hemopexin and 225 therefore was similar to the increase after hemoglobin injection alone. PubMed:28314763
Correlation analysis using Pearson’s correlation coefficient showed statistically significant inverse correlation between Hpx and blood pressure, both systolic (r = -0.511, pvalue< 0.00001, n = 145) and diastolic (r = -0,520, p-value<0.00001, n = 145)(Fig 3). PubMed:26368565
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