Pre-Eclampsia
This could be explained by the finding that CO induces vasodilation by binding to the heme-protein guanylyl cyclase [67]. PubMed:26368565
In line with previously published studies [13,14] the extravascular heme- and radical scavenger A1M was significantly increased in plasma of women with PE. PubMed:26368565
A 4-fold increase of the HbF concentration was seen in the PE patients (p-value 0.01) as compared to the controls. PubMed:26368565
A negative correlation was found, i.e. an increased plasma cell-free HbF concentration was associated with a decreased plasma Hp concentration, when including all individuals, controls and women with PE (r = -0.335, p-value<0.0001, n = 145)(Fig 1A). PubMed:26368565
A statistically significant increase in the mean Hp-HbF concentration was observed for women with PE as compared to controls (p-value 0.018). PubMed:26368565
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.