a(MESH:"haptoglobin-hemoglobin complex")
Because of its large molecular size, this complex is maintained in the intravascular space, preventing the association of otherwise free Hb with nitric oxide (NO; Reiter et al., 2002) and inhibiting the release of free heme (Melamed-Frank et al., 2001). PubMed:24904418
The haptoglobin–haemoglobin complex is recognized by the haemoglobin scavenger receptor, CD163, on the surface of monocytes/macrophages, which mediates haptoglobin–haemoglobin endocytosis and degradation (Kristiansen et al, 2001). PubMed:25307023
Haptoglobin (Hp) is perhaps the most well investigated Hb-clearing molecule. It binds cell-free Hb in plasma [20,21] and the resulting Hp-Hb complex is cleared from blood via binding to the macrophage receptor CD163 [22]. PubMed:26368565
Haptoglobin binds to hemoglobin dimers and forms a high-molecular weight haptoglobin-hemoglobin complex, which is cleared from the circulation after binding to the CD163 receptor on hepatic and splenic macrophages (12). PubMed:28314763
Haptoglobin (Hp) is perhaps the most well investigated Hb-clearing molecule. It binds cell-free Hb in plasma [20,21] and the resulting Hp-Hb complex is cleared from blood via binding to the macrophage receptor CD163 [22]. PubMed:26368565
A statistically significant increase in the mean Hp-HbF concentration was observed for women with PE as compared to controls (p-value 0.018). PubMed:26368565
Formation of large amounts of haptoglobin– haemoglobin complexes rapidly depletes haptoglobin. PubMed:25307023
For example, Hp 2-2 has been associated with an increased susceptibility to diabetic cardiovascular disease; uptake of Hb-Hp(1-1) complexes by CD163 receptors is reportedly faster and its binding results in increased concentrations of anti-inflammatory mediators than Hb-Hp(2-2) complexes; and the angiogenic potency of Hp 2-2 is reportedly greater than that of Hp 1-1 [18]. PubMed:24486321
This result is in accord with recent work, which showed that Hp binding to Hb prevents oxidative damage to the globin. PubMed:24486321
Because of its large molecular size, this complex is maintained in the intravascular space, preventing the association of otherwise free Hb with nitric oxide (NO; Reiter et al., 2002) and inhibiting the release of free heme (Melamed-Frank et al., 2001). PubMed:24904418
Macrophages and liver cells capture large HP-Hb complexes clearing the plasma from free hemoglobin. PubMed:28088643
Haptoglobin (Hp) is perhaps the most well investigated Hb-clearing molecule. It binds cell-free Hb in plasma [20,21] and the resulting Hp-Hb complex is cleared from blood via binding to the macrophage receptor CD163 [22]. PubMed:26368565
A statistically significant increase in the mean Hp-HbF concentration was observed for women with PE as compared to controls (p-value 0.018). PubMed:26368565
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.