Name
Macrophages
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

act(a(CHEBI:nicotine)) increases act(p(HGNC:STAT3)) View Subject | View Object

Downstream from the nicotine-stimulated kinases, a number of transcription factors have been shown to be activated. Among these factors are the cAMP response element binding protein (CREB) and the activating transcription factor 2 (ATF-2) in PC12 cells (211, 337, 460), the Ets-like transcription factor Elk-1 in the rat hippocampus (349), and the signal transducer and activator of transcription (STAT3) in macrophages and skin cells (114, 354). PubMed:19126755

Appears in Networks:
Annotations
MeSH
Macrophages
MeSH
Skin
Text Location
Review

a(CHEBI:heme) increases act(a(CHEBI:Peroxidase)) View Subject | View Object

It is well known that in the presence of H2O2 hemoglobin exhibits a peroxidase-like activity, catalyzed by the heme moiety. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Results

a(MESH:"haptoglobin-hemoglobin complex") decreases p(HGNC:HBB) View Subject | View Object

Macrophages and liver cells capture large HP-Hb complexes clearing the plasma from free hemoglobin. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Introduction

p(HGNC:HPX) causesNoChange act(a(CHEBI:Peroxidase)) View Subject | View Object

However, no changes in peroxidase activity were observed after incubation with haptoglobin or hemopexin (Fig. 2). PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Results

complex(a(CHEBI:heme), p(INTERPRO:"NEAT domain")) decreases act(a(CHEBI:Peroxidase)) View Subject | View Object

At the same time, heme bound to NEAT does not catalyze the peroxidase reaction due to inability to interact with H2O2. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.