Macrophages
Downstream from the nicotine-stimulated kinases, a number of transcription factors have been shown to be activated. Among these factors are the cAMP response element binding protein (CREB) and the activating transcription factor 2 (ATF-2) in PC12 cells (211, 337, 460), the Ets-like transcription factor Elk-1 in the rat hippocampus (349), and the signal transducer and activator of transcription (STAT3) in macrophages and skin cells (114, 354). PubMed:19126755
It is well known that in the presence of H2O2 hemoglobin exhibits a peroxidase-like activity, catalyzed by the heme moiety. PubMed:28088643
Macrophages and liver cells capture large HP-Hb complexes clearing the plasma from free hemoglobin. PubMed:28088643
However, no changes in peroxidase activity were observed after incubation with haptoglobin or hemopexin (Fig. 2). PubMed:28088643
At the same time, heme bound to NEAT does not catalyze the peroxidase reaction due to inability to interact with H2O2. PubMed:28088643
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.