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a(CHEBI:Peroxidase)

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Entity

Name
Peroxidase
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 7

a(CHEBI:heme) increases act(a(CHEBI:Peroxidase)) View Subject | View Object

It is well known that in the presence of H2O2 hemoglobin exhibits a peroxidase-like activity, catalyzed by the heme moiety. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Results

p(HGNC:HPX) causesNoChange act(a(CHEBI:Peroxidase)) View Subject | View Object

However, no changes in peroxidase activity were observed after incubation with haptoglobin or hemopexin (Fig. 2). PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Results

complex(a(CHEBI:heme), p(INTERPRO:"NEAT domain")) decreases act(a(CHEBI:Peroxidase)) View Subject | View Object

At the same time, heme bound to NEAT does not catalyze the peroxidase reaction due to inability to interact with H2O2. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Results

p(INTERPRO:"NEAT domain") decreases act(a(CHEBI:Peroxidase)) View Subject | View Object

Our data demonstrate a significant decrease in peroxidase activity of hemoglobin incubated with NEATHP, indicating heme transfer. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Results

p(INTERPRO:"NEAT domain") decreases act(a(CHEBI:Peroxidase)) View Subject | View Object

Therefore, we demonstrated that an active scavenging of heme by NEAT can reduce peroxidase activity of hemoglobin, whereas passive scavengers cannot. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Results

complex(p(HGNC:HP), p(INTERPRO:"NEAT domain")) decreases act(a(CHEBI:Peroxidase)) View Subject | View Object

Moreover, heme scavenging by NEAT-HP markedly decreased hemoglobin-mediated peroxidase activity (Fig. 2), whereas haptoglobin was capable of only a small attenuation of peroxidase activity and hemopexin did not affect it at all. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Discussion

p(HGNC:HP) causesNoChange act(a(CHEBI:Peroxidase)) View Subject | View Object

However, no changes in peroxidase activity were observed after incubation with haptoglobin or hemopexin (Fig. 2). PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Results

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.