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complex(p(HGNC:HP), p(INTERPRO:"NEAT domain"))

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Components

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Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 0

Out-Edges 4

complex(p(HGNC:HP), p(INTERPRO:"NEAT domain")) hasComponent p(HGNC:HP) View Subject | View Object

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complex(p(HGNC:HP), p(INTERPRO:"NEAT domain")) hasComponent p(INTERPRO:"NEAT domain") View Subject | View Object

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complex(p(HGNC:HP), p(INTERPRO:"NEAT domain")) decreases a(CHEBI:heme) View Subject | View Object

It is seen in Fig. 2 that after incubation with NEAT-HP, Hb has decreased the heme content by 85%, which confirms heme removal ability of NEAT-HP construct. PubMed:28088643

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Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Results

complex(p(HGNC:HP), p(INTERPRO:"NEAT domain")) decreases act(a(CHEBI:Peroxidase)) View Subject | View Object

Moreover, heme scavenging by NEAT-HP markedly decreased hemoglobin-mediated peroxidase activity (Fig. 2), whereas haptoglobin was capable of only a small attenuation of peroxidase activity and hemopexin did not affect it at all. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Discussion

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.