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Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(CHEBI:"desferrioxamine B") negativeCorrelation p(HGNC:CD163) View Subject | View Object

DFX treatment also caused a significant reduction in infiltrating CD163-positive and HO-1 positive cell in the hematoma at day 3 (Figs. 6A and B) and day 7 (Suppl Figures II & III). PubMed:27125525

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MeSH
Cerebral Hemorrhage
Text Location
Results

a(HM:erythrophagocytosis) positiveCorrelation p(HGNC:CD163) View Subject | View Object

Evidence suggested that CD163 acts as a hemoglobin scavenger receptor on microglia/macrophage with a role in erythrophagocytosis. PubMed:27125525

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Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

path(MESH:"Pre-Eclampsia") positiveCorrelation p(HGNC:CD163) View Subject | View Object

Soluble, shedded CD163, the macrophage receptor mediating elimination of the Hp-Hb complex, was analyzed in plasma [40–42]. The analysis showed a small but not statistically significant (p-value 0.37) increase in the PE group as compared to the controls (Table 3). PubMed:26368565

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Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Results

path(MESH:Hematoma) positiveCorrelation p(HGNC:CD163) View Subject | View Object

CD163 and HO-1 positive cells infiltrated into the hematoma from edge to center after ICH (Figs. 4A & 4B). A significant increase of CD163 cells was found at day 3. PubMed:27125525

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MeSH
Cerebral Hemorrhage
Text Location
Results

Out-Edges 8

p(HGNC:CD163) increases deg(a(MESH:"haptoglobin-hemoglobin complex")) View Subject | View Object

The haptoglobin–haemoglobin complex is recognized by the haemoglobin scavenger receptor, CD163, on the surface of monocytes/macrophages, which mediates haptoglobin–haemoglobin endocytosis and degradation (Kristiansen et al, 2001). PubMed:25307023

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Cell Ontology (CL)
macrophage
Text Location
Review

p(HGNC:CD163) decreases a(MESH:"haptoglobin-hemoglobin complex") View Subject | View Object

Haptoglobin (Hp) is perhaps the most well investigated Hb-clearing molecule. It binds cell-free Hb in plasma [20,21] and the resulting Hp-Hb complex is cleared from blood via binding to the macrophage receptor CD163 [22]. PubMed:26368565

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MeSH
Placenta
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Introduction

p(HGNC:CD163) increases deg(a(MESH:"haptoglobin-hemoglobin complex")) View Subject | View Object

Haptoglobin binds to hemoglobin dimers and forms a high-molecular weight haptoglobin-hemoglobin complex, which is cleared from the circulation after binding to the CD163 receptor on hepatic and splenic macrophages (12). PubMed:28314763

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Text Location
Introduction

p(HGNC:CD163) positiveCorrelation path(MESH:"Pre-Eclampsia") View Subject | View Object

Soluble, shedded CD163, the macrophage receptor mediating elimination of the Hp-Hb complex, was analyzed in plasma [40–42]. The analysis showed a small but not statistically significant (p-value 0.37) increase in the PE group as compared to the controls (Table 3). PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Results

p(HGNC:CD163) positiveCorrelation path(MESH:Hematoma) View Subject | View Object

CD163 and HO-1 positive cells infiltrated into the hematoma from edge to center after ICH (Figs. 4A & 4B). A significant increase of CD163 cells was found at day 3. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

p(HGNC:CD163) negativeCorrelation a(CHEBI:"desferrioxamine B") View Subject | View Object

DFX treatment also caused a significant reduction in infiltrating CD163-positive and HO-1 positive cell in the hematoma at day 3 (Figs. 6A and B) and day 7 (Suppl Figures II & III). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

p(HGNC:CD163) positiveCorrelation a(HM:erythrophagocytosis) View Subject | View Object

Evidence suggested that CD163 acts as a hemoglobin scavenger receptor on microglia/macrophage with a role in erythrophagocytosis. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

p(HGNC:CD163) increases p(HGNC:HMOX1) View Subject | View Object

CD163 mediated hemoglobin/hematoma clearance is involved in the induction of HO-1, a rate-limiting enzyme for heme degradation 26. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.