path(MESH:Hematoma)
In combination, these finding may underlie our previous results showing that DFX slows hematoma resolution after ICH in aged rats 12. PubMed:27125525
Erythrophagocytosis was observed in the hematoma edge at day-3 (Fig. 3A), and hemosiderin deposition was identifiable in the hematoma edge at day-7 (Fig. 3A). PubMed:27125525
In this present study, MAC contents in the clot gradually increased with a marked accumulation at day-3 (53.5 ± 8.2 vs. 11.0 ± 3.9 ng/g at 4 hour, p<0.01, Fig. 2C) and stayed at high levels at day 7. PubMed:27125525
Erythrophagocytosis was observed in the hematoma edge at day-3 (Fig. 3A), and hemosiderin deposition was identifiable in the hematoma edge at day-7 (Fig. 3A). PubMed:27125525
Hematomas occur in atheromatous lesions and plaque material contains lipid oxidation products including lipid hydroperoxide22 which can mediate not only the oxidation of hemoglobin but might also lyse intact red cells.23 PubMed:20378845
Atheromatous lesions are prone to disruption leading to hematoma or hemorrhage. PubMed:20378845
We found that diameter of RBC decreased gradually in the hematoma edge and hematoma center (e.g. day-3 at hematoma edge: 2.71 ± 0.38μm vs. 3.89 ± 0.35μm at 4 hours, p<0.01; hematoma center: 2.61 ± 0.29 μm vs. 3.75 ± 0.25μm at 4 hours, p<0.01. Fig. 1). PubMed:27125525
The diameter of RBCs within the hematoma decreased with time after ICH. PubMed:27125525
The hematoma clearance may be via red blood cell (RBC) lysis or phagocytosis. PubMed:27125525
The level of hemoglobin declined gradually over the time after the onset of ICH with a significant reduction at day 3. The contents of hemoglobin in the clot were 26.2 ± 5.2 mg/g at 4 hours, but were reduced to 13.9 ± 0.9 mg/g at day-3 (Fig. 2B, p<0.01). PubMed:27125525
We found that hemoglobin contents in hematoma were significantly higher in the DFX treated group compare to the vehicle-treated group (15.9 ± 1.8 vs. 11.8 ± 0.8 mg/g, p<0.05, Fig. 5A). PubMed:27125525
CD163 and HO-1 positive cells infiltrated into the hematoma from edge to center after ICH (Figs. 4A & 4B). A significant increase of CD163 cells was found at day 3. PubMed:27125525
The current study examined the natural time course of CD47 expression in the hematoma in a swine ICH model and found that CD47 levels in the clot decrease with time. PubMed:27125525
Our recent study showed that depleting CD47 in RBCs resulted in faster hematoma clearance with microglia/ macrophages being less likely to phagocytize RBCs with CD47 than CD47-deficient RBC 7. PubMed:27125525
HO-1 protein levels in the hematoma also increased at day-3 (HO-1/GAPDH: 0.65 ± 0.08 at day-3 vs. 0.04 ± 0.01 at 4 hour, p<0.01). PubMed:27125525
Hematoma resolution occurs in the days after intracerebral hemorrhage (ICH). PubMed:27125525
In this present study, MAC contents in the clot gradually increased with a marked accumulation at day-3 (53.5 ± 8.2 vs. 11.0 ± 3.9 ng/g at 4 hour, p<0.01, Fig. 2C) and stayed at high levels at day 7. PubMed:27125525
Erythrophagocytosis was observed in the hematoma edge at day-3 (Fig. 3A), and hemosiderin deposition was identifiable in the hematoma edge at day-7 (Fig. 3A). PubMed:27125525
Erythrophagocytosis was observed in the hematoma edge at day-3 (Fig. 3A), and hemosiderin deposition was identifiable in the hematoma edge at day-7 (Fig. 3A). PubMed:27125525
Hematomas occur in atheromatous lesions and plaque material contains lipid oxidation products including lipid hydroperoxide22 which can mediate not only the oxidation of hemoglobin but might also lyse intact red cells.23 PubMed:20378845
Atheromatous lesions are prone to disruption leading to hematoma or hemorrhage. PubMed:20378845
Hematoma resolution occurs in the days after intracerebral hemorrhage (ICH). PubMed:27125525
The hematoma clearance may be via red blood cell (RBC) lysis or phagocytosis. PubMed:27125525
We found that diameter of RBC decreased gradually in the hematoma edge and hematoma center (e.g. day-3 at hematoma edge: 2.71 ± 0.38μm vs. 3.89 ± 0.35μm at 4 hours, p<0.01; hematoma center: 2.61 ± 0.29 μm vs. 3.75 ± 0.25μm at 4 hours, p<0.01. Fig. 1). PubMed:27125525
The diameter of RBCs within the hematoma decreased with time after ICH. PubMed:27125525
The level of hemoglobin declined gradually over the time after the onset of ICH with a significant reduction at day 3. The contents of hemoglobin in the clot were 26.2 ± 5.2 mg/g at 4 hours, but were reduced to 13.9 ± 0.9 mg/g at day-3 (Fig. 2B, p<0.01). PubMed:27125525
We found that hemoglobin contents in hematoma were significantly higher in the DFX treated group compare to the vehicle-treated group (15.9 ± 1.8 vs. 11.8 ± 0.8 mg/g, p<0.05, Fig. 5A). PubMed:27125525
CD163 and HO-1 positive cells infiltrated into the hematoma from edge to center after ICH (Figs. 4A & 4B). A significant increase of CD163 cells was found at day 3. PubMed:27125525
HO-1 protein levels in the hematoma also increased at day-3 (HO-1/GAPDH: 0.65 ± 0.08 at day-3 vs. 0.04 ± 0.01 at 4 hour, p<0.01). PubMed:27125525
The current study examined the natural time course of CD47 expression in the hematoma in a swine ICH model and found that CD47 levels in the clot decrease with time. PubMed:27125525
Our recent study showed that depleting CD47 in RBCs resulted in faster hematoma clearance with microglia/ macrophages being less likely to phagocytize RBCs with CD47 than CD47-deficient RBC 7. PubMed:27125525
In combination, these finding may underlie our previous results showing that DFX slows hematoma resolution after ICH in aged rats 12. PubMed:27125525
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.