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a(MESH:"Complement Membrane Attack Complex")

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Entity

Name
Complement Membrane Attack Complex
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 15

a(CHEBI:"desferrioxamine B") negativeCorrelation a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

DFX also reduced the MAC content in the clot at day-3 (33.0 ± 6.6 vs. 56.2 ± 9.2 ng/g in the vehicle-treated group, p<0.05, Fig. 5B). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

a(CHEBI:"desferrioxamine B") negativeCorrelation a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

The present study found that DFX treatment reduces MAC formation in the clot. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Stroke
Text Location
Discussion

a(CHEBI:heme) increases a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

C3a and C5a anaphylatoxins, as well as the soluble membrane attack complex (sC5b9), are generated by incubation of heme with human serum or blood in vitro, via the alternative complement pathway [33,77] (Box 5). PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

bp(MESH:"Cell Membrane Permeability") positiveCorrelation a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

Activation of the complement system and the formation of MAC resulted in an increased membrane permeability and erythrocyte lysis. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

bp(MESH:"Cell Membrane Permeability") positiveCorrelation a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

Following complement cascade activation, MAC on the cell membrane forms a pore resulting in membrane permeability changes17 finally leading to RBC morphological alterations and erythrocyte lysis. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Discussion

p(HGNC:CD59) negativeCorrelation act(a(MESH:"Complement Membrane Attack Complex")) View Subject | View Object

The endothelium normally expresses high levels of CD59, which protects endothelial cells in healthy individuals and in PNH patients from MAC-mediated injury. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

p(HGNC:CD59, var("p.Cys89Tyr")) positiveCorrelation a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

As shown in Fig. 1, significantly increased MAC deposition is seen on RBCs (p < 0.0003), neutrophils (p < 0.009), and platelets (p < 0.0003), but not on monocytes (p=0.5, not shown). PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Cell Ontology (CL)
neutrophil
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Results

p(HGNC:CD59, var("p.Cys89Tyr")) causesNoChange a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

As shown in Fig. 1, significantly increased MAC deposition is seen on RBCs (p < 0.0003), neutrophils (p < 0.009), and platelets (p < 0.0003), but not on monocytes (p=0.5, not shown). PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Results

p(HGNC:CD59, var("p.Cys89Tyr")) positiveCorrelation act(a(MESH:"Complement Membrane Attack Complex")) View Subject | View Object

However, in primary Cys89Tyr CD59 deficiency and not in PNH, the endothelial cells are exposed to MACmediated injury. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

path(MESH:Hematoma) positiveCorrelation a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

In this present study, MAC contents in the clot gradually increased with a marked accumulation at day-3 (53.5 ± 8.2 vs. 11.0 ± 3.9 ng/g at 4 hour, p<0.01, Fig. 2C) and stayed at high levels at day 7. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

path(MESH:Hemolysis) positiveCorrelation a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

Erythrocyte lysis after ICH can be mediated by the complement activation and formation of the membrane attack complex (MAC), which contains complement C5b, C6, C7, C8 and C9 proteins (C5b– 9). PubMed:27125525

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Hemolysis) positiveCorrelation a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

Activation of the complement system and the formation of MAC resulted in an increased membrane permeability and erythrocyte lysis. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

path(MESH:Hemolysis) positiveCorrelation a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

Following complement cascade activation, MAC on the cell membrane forms a pore resulting in membrane permeability changes17 finally leading to RBC morphological alterations and erythrocyte lysis. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Discussion

path(MESH:Hemolysis) positiveCorrelation a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

Increased MAC deposition may lead to cell lysis and hemolysis, as is usually seen in RBCs but to a lesser extent in neutrophils and platelets (please see below). PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Cell Ontology (CL)
neutrophil
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Results

path(MESH:Hemolysis) positiveCorrelation a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

Following MAC deposition on RBCs, intravascular hemolysis that leads to increasing levels of free hemoglobin was seen. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Cell Ontology (CL)
neutrophil
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Results

Out-Edges 15

a(MESH:"Complement Membrane Attack Complex") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Erythrocyte lysis after ICH can be mediated by the complement activation and formation of the membrane attack complex (MAC), which contains complement C5b, C6, C7, C8 and C9 proteins (C5b– 9). PubMed:27125525

Appears in Networks:
Annotations
Text Location
Introduction

a(MESH:"Complement Membrane Attack Complex") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Activation of the complement system and the formation of MAC resulted in an increased membrane permeability and erythrocyte lysis. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

a(MESH:"Complement Membrane Attack Complex") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Following complement cascade activation, MAC on the cell membrane forms a pore resulting in membrane permeability changes17 finally leading to RBC morphological alterations and erythrocyte lysis. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Discussion

a(MESH:"Complement Membrane Attack Complex") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Increased MAC deposition may lead to cell lysis and hemolysis, as is usually seen in RBCs but to a lesser extent in neutrophils and platelets (please see below). PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Cell Ontology (CL)
neutrophil
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Results

a(MESH:"Complement Membrane Attack Complex") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Following MAC deposition on RBCs, intravascular hemolysis that leads to increasing levels of free hemoglobin was seen. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Cell Ontology (CL)
neutrophil
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Results

a(MESH:"Complement Membrane Attack Complex") increases path(MESH:Hemolysis) View Subject | View Object

Ultimately, activation of the complement cascade results in formation of the terminal complement complex C5b-9, the so-called membrane attack complex, and consequently a pore formation resulting in osmotic lysis of the target [71]. In the case of red blood cells, hemolysis will result. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Hemolysis
Text Location
Review

a(MESH:"Complement Membrane Attack Complex") positiveCorrelation bp(MESH:"Cell Membrane Permeability") View Subject | View Object

Activation of the complement system and the formation of MAC resulted in an increased membrane permeability and erythrocyte lysis. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

a(MESH:"Complement Membrane Attack Complex") positiveCorrelation bp(MESH:"Cell Membrane Permeability") View Subject | View Object

Following complement cascade activation, MAC on the cell membrane forms a pore resulting in membrane permeability changes17 finally leading to RBC morphological alterations and erythrocyte lysis. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Discussion

a(MESH:"Complement Membrane Attack Complex") positiveCorrelation path(MESH:Hematoma) View Subject | View Object

In this present study, MAC contents in the clot gradually increased with a marked accumulation at day-3 (53.5 ± 8.2 vs. 11.0 ± 3.9 ng/g at 4 hour, p<0.01, Fig. 2C) and stayed at high levels at day 7. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

a(MESH:"Complement Membrane Attack Complex") negativeCorrelation a(CHEBI:"desferrioxamine B") View Subject | View Object

DFX also reduced the MAC content in the clot at day-3 (33.0 ± 6.6 vs. 56.2 ± 9.2 ng/g in the vehicle-treated group, p<0.05, Fig. 5B). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

a(MESH:"Complement Membrane Attack Complex") negativeCorrelation a(CHEBI:"desferrioxamine B") View Subject | View Object

The present study found that DFX treatment reduces MAC formation in the clot. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Stroke
Text Location
Discussion

a(MESH:"Complement Membrane Attack Complex") positiveCorrelation p(HGNC:CD59, var("p.Cys89Tyr")) View Subject | View Object

As shown in Fig. 1, significantly increased MAC deposition is seen on RBCs (p < 0.0003), neutrophils (p < 0.009), and platelets (p < 0.0003), but not on monocytes (p=0.5, not shown). PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Cell Ontology (CL)
neutrophil
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Results

act(a(MESH:"Complement Membrane Attack Complex")) positiveCorrelation p(HGNC:CD59, var("p.Cys89Tyr")) View Subject | View Object

However, in primary Cys89Tyr CD59 deficiency and not in PNH, the endothelial cells are exposed to MACmediated injury. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

act(a(MESH:"Complement Membrane Attack Complex")) negativeCorrelation p(HGNC:CD59) View Subject | View Object

The endothelium normally expresses high levels of CD59, which protects endothelial cells in healthy individuals and in PNH patients from MAC-mediated injury. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

a(MESH:"Complement Membrane Attack Complex") increases bp(GO:cytolysis) View Subject | View Object

Ultimately, activation of the complement cascade results in formation of the terminal complement complex C5b-9, the so-called membrane attack complex, and consequently a pore formation resulting in osmotic lysis of the target [71]. In the case of red blood cells, hemolysis will result. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Hemolysis
Text Location
Review

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.