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p(HGNC:CD59)

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Entity

Name
CD59
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

act(a(MESH:"Complement Membrane Attack Complex")) negativeCorrelation p(HGNC:CD59) View Subject | View Object

The endothelium normally expresses high levels of CD59, which protects endothelial cells in healthy individuals and in PNH patients from MAC-mediated injury. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

path(HP:"Arterial thrombosis") negativeCorrelation p(HGNC:CD59) View Subject | View Object

Interestingly, we have recently reported an association with venous thrombosis for lack of CD55 [45], so PNH patients lacking both CD55 and CD59 may suffer from both venous and arterial thrombosis. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Coronary Vessels
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

path(HP:"Paroxysmal nocturnal hemoglobinuria") negativeCorrelation p(HGNC:CD59) View Subject | View Object

CD59 deficiency is a common finding in adult patients with PNH, which is characterized by clonal expansion of hematopoietic stem cells that have acquired a mutation in the PIGA gene (phosphatidylinositol glycan anchor biosynthesis, class A). PubMed:29929138

Appears in Networks:
Annotations
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Introduction

path(HP:"Venous thrombosis") negativeCorrelation p(HGNC:CD59) View Subject | View Object

Interestingly, we have recently reported an association with venous thrombosis for lack of CD55 [45], so PNH patients lacking both CD55 and CD59 may suffer from both venous and arterial thrombosis. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Coronary Vessels
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

path(MESH:Hemolysis) negativeCorrelation p(HGNC:CD59) View Subject | View Object

PIGA encodes a GPI biosynthesis protein, phosphatidylinositol N-acetylglucosaminyltransferase subunit A [5, 6], and erythrocytes deficient in GPI-anchored membrane proteins, including CD59, undergo complement-mediated hemolysis. PubMed:29929138

Appears in Networks:
Annotations
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Introduction

Out-Edges 7

p(HGNC:CD59) hasVariant p(HGNC:CD59, var("p.Cys89Tyr")) View Subject | View Object

Appears in Networks:

p(HGNC:CD59) decreases path(MESH:Hemolysis) View Subject | View Object

This scenario may resemble that of paroxysmal nocturnal hemoglobinuria patients, who can be treated with complement C5- blocking antibody eculizumab [80]; in this example, extravascular hemolysis has been shown to occur in a small number of these patients despite treatment. It has been suggested that this is due to erythrophagocytosis of red blood cells deficient in the C3d-opsonized complement regulators – CD55 and CD59 [81,82]. PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Malaria
Text Location
Review

p(HGNC:CD59) negativeCorrelation path(MESH:Hemolysis) View Subject | View Object

PIGA encodes a GPI biosynthesis protein, phosphatidylinositol N-acetylglucosaminyltransferase subunit A [5, 6], and erythrocytes deficient in GPI-anchored membrane proteins, including CD59, undergo complement-mediated hemolysis. PubMed:29929138

Appears in Networks:
Annotations
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Introduction

p(HGNC:CD59) negativeCorrelation path(HP:"Paroxysmal nocturnal hemoglobinuria") View Subject | View Object

CD59 deficiency is a common finding in adult patients with PNH, which is characterized by clonal expansion of hematopoietic stem cells that have acquired a mutation in the PIGA gene (phosphatidylinositol glycan anchor biosynthesis, class A). PubMed:29929138

Appears in Networks:
Annotations
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Introduction

p(HGNC:CD59) negativeCorrelation act(a(MESH:"Complement Membrane Attack Complex")) View Subject | View Object

The endothelium normally expresses high levels of CD59, which protects endothelial cells in healthy individuals and in PNH patients from MAC-mediated injury. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

p(HGNC:CD59) negativeCorrelation path(HP:"Arterial thrombosis") View Subject | View Object

Interestingly, we have recently reported an association with venous thrombosis for lack of CD55 [45], so PNH patients lacking both CD55 and CD59 may suffer from both venous and arterial thrombosis. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Coronary Vessels
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

p(HGNC:CD59) negativeCorrelation path(HP:"Venous thrombosis") View Subject | View Object

Interestingly, we have recently reported an association with venous thrombosis for lack of CD55 [45], so PNH patients lacking both CD55 and CD59 may suffer from both venous and arterial thrombosis. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Coronary Vessels
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.