1. Catalog
  2. Nodes
  3. a(HM:erythrophagocytosis)

a(HM:erythrophagocytosis)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
erythrophagocytosis
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 6

bp(GO:"complement activation, alternative pathway") positiveCorrelation a(HM:erythrophagocytosis) View Subject | View Object

It is possible that heme-induced overactivation of the alternative complement pathway, and depo- sition of C3 fragments on erythrocyte membranes, participate in erythrophagocytosis of uninfected red blood cells in severe forms of malaria [77]. PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Malaria
Text Location
Review

p(HGNC:CD163) positiveCorrelation a(HM:erythrophagocytosis) View Subject | View Object

Evidence suggested that CD163 acts as a hemoglobin scavenger receptor on microglia/macrophage with a role in erythrophagocytosis. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

complex(p(HGNC:CD47), p(HGNC:SIRPA)) negativeCorrelation a(HM:erythrophagocytosis) View Subject | View Object

CD47 exerts its inhibitory effect on phagocytosis through binding to inhibitory immunoreceptor SIRPα expressed by microglia/macrophages 21.Thus, the CD47-SIRPα constitutes a negative feedback for erythrophagocytosis22. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

p(MGI:Slc40a1) positiveCorrelation a(HM:erythrophagocytosis) View Subject | View Object

High ferroportin levels were measured in macrophages upon heme overload and erythrophagocytosis (12, 13, 31, 32, 37) and in hemolytic murine models of b-thalassemia and phenylhydrazineinduced hemolytic anemia (11, 22, 34). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Introduction

p(HGNC:HMOX1) positiveCorrelation a(HM:erythrophagocytosis) View Subject | View Object

A recent study, however, indicated that HO-1 is associated with blood clearance by enhancing erythrophagocytosis after stroke. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Stroke
Text Location
Discussion

path(MESH:Hematoma) positiveCorrelation a(HM:erythrophagocytosis) View Subject | View Object

Erythrophagocytosis was observed in the hematoma edge at day-3 (Fig. 3A), and hemosiderin deposition was identifiable in the hematoma edge at day-7 (Fig. 3A). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

Out-Edges 7

a(HM:erythrophagocytosis) decreases bp(MESH:"Erythrocyte Count") View Subject | View Object

The mechanism behind this erythrocyte loss is not well understood but may be related to reduced erythrocyte deformability, accelerated senescence, or to complement or antibody-mediated (anti-erythrocyte) erythrophagocytosis [79]. PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Anemia, Sickle Cell
Text Location
Review

a(HM:erythrophagocytosis) positiveCorrelation bp(GO:"complement activation, alternative pathway") View Subject | View Object

It is possible that heme-induced overactivation of the alternative complement pathway, and depo- sition of C3 fragments on erythrocyte membranes, participate in erythrophagocytosis of uninfected red blood cells in severe forms of malaria [77]. PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Malaria
Text Location
Review

a(HM:erythrophagocytosis) positiveCorrelation path(MESH:Hematoma) View Subject | View Object

Erythrophagocytosis was observed in the hematoma edge at day-3 (Fig. 3A), and hemosiderin deposition was identifiable in the hematoma edge at day-7 (Fig. 3A). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

a(HM:erythrophagocytosis) negativeCorrelation complex(p(HGNC:CD47), p(HGNC:SIRPA)) View Subject | View Object

CD47 exerts its inhibitory effect on phagocytosis through binding to inhibitory immunoreceptor SIRPα expressed by microglia/macrophages 21.Thus, the CD47-SIRPα constitutes a negative feedback for erythrophagocytosis22. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

a(HM:erythrophagocytosis) positiveCorrelation p(HGNC:CD163) View Subject | View Object

Evidence suggested that CD163 acts as a hemoglobin scavenger receptor on microglia/macrophage with a role in erythrophagocytosis. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

a(HM:erythrophagocytosis) positiveCorrelation p(HGNC:HMOX1) View Subject | View Object

A recent study, however, indicated that HO-1 is associated with blood clearance by enhancing erythrophagocytosis after stroke. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Stroke
Text Location
Discussion

a(HM:erythrophagocytosis) positiveCorrelation p(MGI:Slc40a1) View Subject | View Object

High ferroportin levels were measured in macrophages upon heme overload and erythrophagocytosis (12, 13, 31, 32, 37) and in hemolytic murine models of b-thalassemia and phenylhydrazineinduced hemolytic anemia (11, 22, 34). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.