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complex(p(HGNC:CD47), p(HGNC:SIRPA))

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Components

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

a(HM:erythrophagocytosis) negativeCorrelation complex(p(HGNC:CD47), p(HGNC:SIRPA)) View Subject | View Object

CD47 exerts its inhibitory effect on phagocytosis through binding to inhibitory immunoreceptor SIRPα expressed by microglia/macrophages 21.Thus, the CD47-SIRPα constitutes a negative feedback for erythrophagocytosis22. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

Out-Edges 3

complex(p(HGNC:CD47), p(HGNC:SIRPA)) hasComponent p(HGNC:CD47) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CD47), p(HGNC:SIRPA)) hasComponent p(HGNC:SIRPA) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CD47), p(HGNC:SIRPA)) negativeCorrelation a(HM:erythrophagocytosis) View Subject | View Object

CD47 exerts its inhibitory effect on phagocytosis through binding to inhibitory immunoreceptor SIRPα expressed by microglia/macrophages 21.Thus, the CD47-SIRPα constitutes a negative feedback for erythrophagocytosis22. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.