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p(HGNC:CD47)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CD47
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(CHEBI:"desferrioxamine B") positiveCorrelation p(HGNC:CD47) View Subject | View Object

DFX also reduced CD47 loss and microglia/macrophage infiltration after ICH suggesting it also affects erythrophagocytosis. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Stroke
Text Location
Discussion

a(CHEBI:"desferrioxamine B") positiveCorrelation p(HGNC:CD47) View Subject | View Object

The loss of CD47 in the clot was reduced significantly by DFX treatment at day 3 (CD47/GAPDH: 1.32 ± 0.16 in ICH+DFX group vs. 0.74 ± 0.07 in ICH + vehicle group, p<0.05, Fig. 5C) and day 7 (p<0.01, Suppl Figure I). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

complex(p(HGNC:CD47), p(HGNC:SIRPA)) hasComponent p(HGNC:CD47) View Subject | View Object

Appears in Networks:

path(MESH:Hematoma) negativeCorrelation p(HGNC:CD47) View Subject | View Object

The current study examined the natural time course of CD47 expression in the hematoma in a swine ICH model and found that CD47 levels in the clot decrease with time. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Discussion

path(MESH:Hematoma) negativeCorrelation p(HGNC:CD47) View Subject | View Object

Our recent study showed that depleting CD47 in RBCs resulted in faster hematoma clearance with microglia/ macrophages being less likely to phagocytize RBCs with CD47 than CD47-deficient RBC 7. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

Out-Edges 4

p(HGNC:CD47) positiveCorrelation a(CHEBI:"desferrioxamine B") View Subject | View Object

The loss of CD47 in the clot was reduced significantly by DFX treatment at day 3 (CD47/GAPDH: 1.32 ± 0.16 in ICH+DFX group vs. 0.74 ± 0.07 in ICH + vehicle group, p<0.05, Fig. 5C) and day 7 (p<0.01, Suppl Figure I). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

p(HGNC:CD47) positiveCorrelation a(CHEBI:"desferrioxamine B") View Subject | View Object

DFX also reduced CD47 loss and microglia/macrophage infiltration after ICH suggesting it also affects erythrophagocytosis. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Stroke
Text Location
Discussion

p(HGNC:CD47) negativeCorrelation path(MESH:Hematoma) View Subject | View Object

The current study examined the natural time course of CD47 expression in the hematoma in a swine ICH model and found that CD47 levels in the clot decrease with time. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Discussion

p(HGNC:CD47) negativeCorrelation path(MESH:Hematoma) View Subject | View Object

Our recent study showed that depleting CD47 in RBCs resulted in faster hematoma clearance with microglia/ macrophages being less likely to phagocytize RBCs with CD47 than CD47-deficient RBC 7. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.