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bp(HM:"Atheromatous lesions")

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Entity

Name
Atheromatous lesions
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 7

a(CHEBI:"lipid hydroperoxide") positiveCorrelation bp(HM:"Atheromatous lesions") View Subject | View Object

Levels of conjugated dienes, lipid hydroperoxides and TBARs were significantly higher in atheromatous lesions compared to controls (supplemental Table I). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(CHEBI:oxysterol) positiveCorrelation bp(HM:"Atheromatous lesions") View Subject | View Object

Oxysterols and oxidation products of polyunsaturated fatty acids (PUFAs) are present in human atheromatous lesions.4,5 PubMed:20378845

Appears in Networks:

a(MESH:"Thiobarbituric Acid Reactive Substances") positiveCorrelation bp(HM:"Atheromatous lesions") View Subject | View Object

Levels of conjugated dienes, lipid hydroperoxides and TBARs were significantly higher in atheromatous lesions compared to controls (supplemental Table I). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

p(HGNC:HMOX1) positiveCorrelation bp(HM:"Atheromatous lesions") View Subject | View Object

Elevated amounts of HO-1 were found in macrophages and medial smooth muscle cells of human atherosclerotic lesions.15 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

path(MESH:Hematoma) positiveCorrelation bp(HM:"Atheromatous lesions") View Subject | View Object

Hematomas occur in atheromatous lesions and plaque material contains lipid oxidation products including lipid hydroperoxide22 which can mediate not only the oxidation of hemoglobin but might also lyse intact red cells.23 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Results

path(MESH:Hematoma) positiveCorrelation bp(HM:"Atheromatous lesions") View Subject | View Object

Atheromatous lesions are prone to disruption leading to hematoma or hemorrhage. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Discussion

path(MESH:Hemorrhage) positiveCorrelation bp(HM:"Atheromatous lesions") View Subject | View Object

Atheromatous lesions are prone to disruption leading to hematoma or hemorrhage. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Discussion

Out-Edges 8

bp(HM:"Atheromatous lesions") positiveCorrelation a(CHEBI:oxysterol) View Subject | View Object

Oxysterols and oxidation products of polyunsaturated fatty acids (PUFAs) are present in human atheromatous lesions.4,5 PubMed:20378845

Appears in Networks:

bp(HM:"Atheromatous lesions") positiveCorrelation path(MESH:Hematoma) View Subject | View Object

Hematomas occur in atheromatous lesions and plaque material contains lipid oxidation products including lipid hydroperoxide22 which can mediate not only the oxidation of hemoglobin but might also lyse intact red cells.23 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Results

bp(HM:"Atheromatous lesions") positiveCorrelation path(MESH:Hematoma) View Subject | View Object

Atheromatous lesions are prone to disruption leading to hematoma or hemorrhage. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Discussion

bp(HM:"Atheromatous lesions") increases a(HM:"Erythrocytes, lysed") View Subject | View Object

Lipids of atheromatous (Fig 1A, 1b and 2b panels) and ruptured complicated lesions (Fig 1A, 1c and 2c panels) as well as oxidized LDL caused significant lysis of red cells within 24 hours (Fig 1B, black bars). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

bp(HM:"Atheromatous lesions") positiveCorrelation a(CHEBI:"lipid hydroperoxide") View Subject | View Object

Levels of conjugated dienes, lipid hydroperoxides and TBARs were significantly higher in atheromatous lesions compared to controls (supplemental Table I). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

bp(HM:"Atheromatous lesions") positiveCorrelation a(MESH:"Thiobarbituric Acid Reactive Substances") View Subject | View Object

Levels of conjugated dienes, lipid hydroperoxides and TBARs were significantly higher in atheromatous lesions compared to controls (supplemental Table I). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

bp(HM:"Atheromatous lesions") positiveCorrelation path(MESH:Hemorrhage) View Subject | View Object

Atheromatous lesions are prone to disruption leading to hematoma or hemorrhage. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Discussion

bp(HM:"Atheromatous lesions") positiveCorrelation p(HGNC:HMOX1) View Subject | View Object

Elevated amounts of HO-1 were found in macrophages and medial smooth muscle cells of human atherosclerotic lesions.15 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Atherosclerosis
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.