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a(HM:"Erythrocytes, lysed")

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Entity

Name
Erythrocytes, lysed
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 11

a(CHEBI:"lipid hydroperoxide") positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

Hematomas occur in atheromatous lesions and plaque material contains lipid oxidation products including lipid hydroperoxide22 which can mediate not only the oxidation of hemoglobin but might also lyse intact red cells.23 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(CHEBI:"oxidised LDL") increases a(HM:"Erythrocytes, lysed") View Subject | View Object

Lipids of atheromatous (Fig 1A, 1b and 2b panels) and ruptured complicated lesions (Fig 1A, 1c and 2c panels) as well as oxidized LDL caused significant lysis of red cells within 24 hours (Fig 1B, black bars). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"Atheroma lipid") increases a(HM:"Erythrocytes, lysed") View Subject | View Object

Lipids of atheromatous (Fig 1A, 1b and 2b panels) and ruptured complicated lesions (Fig 1A, 1c and 2c panels) as well as oxidized LDL caused significant lysis of red cells within 24 hours (Fig 1B, black bars). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(MESH:"Glutathione Peroxidase") decreases a(HM:"Erythrocytes, lysed") View Subject | View Object

Preincubation of lipid extract derived from atheroma, complicated lesion or oxidized LDL with glutathione/glutathione peroxidase (which specifically reduced lipid hydroperoxide to alcohol by 35%, 38% and 90%, respectively) significantly lowered the lytic effect (Fig 1B, empty bars).Oxidation of liberated hemoglobin was also reduced (Fig 1C, empty bars) PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

bp(HM:"Atheromatous lesions") increases a(HM:"Erythrocytes, lysed") View Subject | View Object

Lipids of atheromatous (Fig 1A, 1b and 2b panels) and ruptured complicated lesions (Fig 1A, 1c and 2c panels) as well as oxidized LDL caused significant lysis of red cells within 24 hours (Fig 1B, black bars). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

act(p(PFAM:Ferritin)) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

There was a marked increase in periventricular ferritin immunoreactivity after injection of lysed RBCs (Figure 3A) compared with saline or packed RBC injection. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

p(PFAM:Ferritin) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

p(RGD:Fth1) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

Injection of lysed RBCs resulted in higher protein levels of ferritin heavy chain (2,350±429 pixels vs. 800±326 pixels in packed RBC group, Po0.01, Figure 3B) and ferritin light chain (Po0.01, Figure 3C), compared with saline or packed RBCs. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

p(RGD:Ftl1) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

Injection of lysed RBCs resulted in higher protein levels of ferritin heavy chain (2,350±429 pixels vs. 800±326 pixels in packed RBC group, Po0.01, Figure 3B) and ferritin light chain (Po0.01, Figure 3C), compared with saline or packed RBCs. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

path(MESH:Hydrocephalus) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

Injection of lysed RBCs resulted in significantly larger ventricular volumes (lateral ventricle volume 67.9±10.0mm3) compared with injection of packed RBCs (24.1±6.2mm3, Po0.01) and saline (Po0.01) at 24 hours (Figure 1). PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

path(MESH:Hydrocephalus) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

Out-Edges 12

a(HM:"Erythrocytes, lysed") positiveCorrelation a(CHEBI:"lipid hydroperoxide") View Subject | View Object

Hematomas occur in atheromatous lesions and plaque material contains lipid oxidation products including lipid hydroperoxide22 which can mediate not only the oxidation of hemoglobin but might also lyse intact red cells.23 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"Erythrocytes, lysed") increases p(HGNC:HBB) View Subject | View Object

The results reported here indicate that, once exposed to oxidized plaque material, erythrocytes are lysed, the liberated hemoglobin is oxidized and heme dissociates from the resultant ferrihemoglobin. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Discussion

a(HM:"Erythrocytes, lysed") positiveCorrelation path(MESH:Hydrocephalus) View Subject | View Object

Injection of lysed RBCs resulted in significantly larger ventricular volumes (lateral ventricle volume 67.9±10.0mm3) compared with injection of packed RBCs (24.1±6.2mm3, Po0.01) and saline (Po0.01) at 24 hours (Figure 1). PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

a(HM:"Erythrocytes, lysed") positiveCorrelation path(MESH:Hydrocephalus) View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

a(HM:"Erythrocytes, lysed") increases p(RGD:Hmox1) View Subject | View Object

There were many more periventricular HO-1-positive cells after injection of lysed RBCs than after saline or packed RBC injection. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

a(HM:"Erythrocytes, lysed") increases p(RGD:Hmox1) View Subject | View Object

HO-1 protein levels in the periventricular area were significantly increased in rats receiving lysed RBCs (3,566±2,481 pixels vs. 115±141 pixels in saline group and 295±311 pixels in the packed RBC group, Po0.05, Figure 2). PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

a(HM:"Erythrocytes, lysed") increases p(RGD:Hmox1) View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

a(HM:"Erythrocytes, lysed") positiveCorrelation act(p(PFAM:Ferritin)) View Subject | View Object

There was a marked increase in periventricular ferritin immunoreactivity after injection of lysed RBCs (Figure 3A) compared with saline or packed RBC injection. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

a(HM:"Erythrocytes, lysed") positiveCorrelation p(PFAM:Ferritin) View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

a(HM:"Erythrocytes, lysed") positiveCorrelation p(RGD:Ftl1) View Subject | View Object

Injection of lysed RBCs resulted in higher protein levels of ferritin heavy chain (2,350±429 pixels vs. 800±326 pixels in packed RBC group, Po0.01, Figure 3B) and ferritin light chain (Po0.01, Figure 3C), compared with saline or packed RBCs. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

a(HM:"Erythrocytes, lysed") positiveCorrelation p(RGD:Fth1) View Subject | View Object

Injection of lysed RBCs resulted in higher protein levels of ferritin heavy chain (2,350±429 pixels vs. 800±326 pixels in packed RBC group, Po0.01, Figure 3B) and ferritin light chain (Po0.01, Figure 3C), compared with saline or packed RBCs. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

a(HM:"Erythrocytes, lysed") increases a(MESH:Arginase) View Subject | View Object

In addition, lysed erythrocytes release arginase, which catalyzes the conversion of arginine, the substrate for NO synthesis, to ornithine. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.