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path(MESH:Hydrocephalus)

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Entity

Name
Hydrocephalus
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 7

a(CHEBI:"desferrioxamine B") negativeCorrelation path(MESH:Hydrocephalus) View Subject | View Object

Coinjection of deferoxamine with lysed RBC reduced ventricular enlargement (47.8±17.8 vs. 59.9±15.7mm3 in saline coinjection group, Po0.05, Figure 6). PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

a(CHEBI:"desferrioxamine B") negativeCorrelation path(MESH:Hydrocephalus) View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:Hydrocephalus) View Subject | View Object

Twenty-four hours after injection, T2 MRI showed a significant bilateral ventricular enlargement in the iron-injected group (17.9±5.7mm3) compared with salineinjected rats (9.2±5.7mm3, Po0.01, Figure 4). PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

a(CHEBI:"iron(2+)") positiveCorrelation path(MESH:Hydrocephalus) View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

a(HM:"Erythrocytes, lysed") positiveCorrelation path(MESH:Hydrocephalus) View Subject | View Object

Injection of lysed RBCs resulted in significantly larger ventricular volumes (lateral ventricle volume 67.9±10.0mm3) compared with injection of packed RBCs (24.1±6.2mm3, Po0.01) and saline (Po0.01) at 24 hours (Figure 1). PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

a(HM:"Erythrocytes, lysed") positiveCorrelation path(MESH:Hydrocephalus) View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

a(MESH:Thrombin) positiveCorrelation path(MESH:Hydrocephalus) View Subject | View Object

Our most recent study has shown that thrombin and thrombin receptor are involved in IVH-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

Out-Edges 7

path(MESH:Hydrocephalus) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

Injection of lysed RBCs resulted in significantly larger ventricular volumes (lateral ventricle volume 67.9±10.0mm3) compared with injection of packed RBCs (24.1±6.2mm3, Po0.01) and saline (Po0.01) at 24 hours (Figure 1). PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

path(MESH:Hydrocephalus) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

path(MESH:Hydrocephalus) positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

Twenty-four hours after injection, T2 MRI showed a significant bilateral ventricular enlargement in the iron-injected group (17.9±5.7mm3) compared with salineinjected rats (9.2±5.7mm3, Po0.01, Figure 4). PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

path(MESH:Hydrocephalus) positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

path(MESH:Hydrocephalus) negativeCorrelation a(CHEBI:"desferrioxamine B") View Subject | View Object

Coinjection of deferoxamine with lysed RBC reduced ventricular enlargement (47.8±17.8 vs. 59.9±15.7mm3 in saline coinjection group, Po0.05, Figure 6). PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

path(MESH:Hydrocephalus) negativeCorrelation a(CHEBI:"desferrioxamine B") View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

path(MESH:Hydrocephalus) positiveCorrelation a(MESH:Thrombin) View Subject | View Object

Our most recent study has shown that thrombin and thrombin receptor are involved in IVH-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.