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a(CHEBI:"oxidised LDL")

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Entity

Name
oxidised LDL
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

a(CHEBI:heme) positiveCorrelation a(CHEBI:"oxidised LDL") View Subject | View Object

In fact, heme-induced LDL oxidation is highly cytotoxic for endothelial cells and LDL oxidation seems to be mediated by Fe (Jeney et al., 2002; Nagy et al., 2010). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

bp(MESH:"Cytotoxicity, Immunologic") positiveCorrelation a(CHEBI:"oxidised LDL") View Subject | View Object

Heme/iron-mediated oxidative modification of LDL can cause endothelial cytotoxicity8,24 and – at sublethal doses – the expression of stress-response genes.9,11-14 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

complex(a(CHEBI:"oxidised LDL"), a(MESH:"Glutathione Peroxidase")) hasComponent a(CHEBI:"oxidised LDL") View Subject | View Object

Appears in Networks:

p(HGNC:FTH1) decreases a(CHEBI:"oxidised LDL") View Subject | View Object

Cells deficient on FtH are more susceptible to oxidative damage, while increased amounts of FtH protects cells from death induced by challenges such as Fe, tumor necrosis factor (TNF), heme, heme plus TNF, or oxidized low-density lipoprotein (LDL; Juckett et al., 1995; Pham et al., 2004; Gozzelino et al., 2012). PubMed:24904418

Appears in Networks:
Annotations
Text Location
Review

Out-Edges 8

a(CHEBI:"oxidised LDL") increases p(HGNC:HMOX1) View Subject | View Object

In previous studies we found that endothelial cells exposed to oxidized LDL upregulated both heme oxygenase-1 (HO-1) and ferritin,8,9 presumably as a defense mechanism.6,11-14 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell

a(CHEBI:"oxidised LDL") increases p(HGNC:HMOX1) View Subject | View Object

Upregulation of HO-115 and ferritin H chain16 in endothelial cells has been reported in the early phase of progression of atherosclerotic lesions. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis

a(CHEBI:"oxidised LDL") increases p(PFAM:Ferritin) View Subject | View Object

In previous studies we found that endothelial cells exposed to oxidized LDL upregulated both heme oxygenase-1 (HO-1) and ferritin,8,9 presumably as a defense mechanism.6,11-14 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell

a(CHEBI:"oxidised LDL") increases p(PFAM:Ferritin) View Subject | View Object

Upregulation of HO-115 and ferritin H chain16 in endothelial cells has been reported in the early phase of progression of atherosclerotic lesions. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis

a(CHEBI:"oxidised LDL") increases a(HM:"Erythrocytes, lysed") View Subject | View Object

Lipids of atheromatous (Fig 1A, 1b and 2b panels) and ruptured complicated lesions (Fig 1A, 1c and 2c panels) as well as oxidized LDL caused significant lysis of red cells within 24 hours (Fig 1B, black bars). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(CHEBI:"oxidised LDL") positiveCorrelation bp(MESH:"Cytotoxicity, Immunologic") View Subject | View Object

Heme/iron-mediated oxidative modification of LDL can cause endothelial cytotoxicity8,24 and – at sublethal doses – the expression of stress-response genes.9,11-14 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(CHEBI:"oxidised LDL") positiveCorrelation a(CHEBI:heme) View Subject | View Object

In fact, heme-induced LDL oxidation is highly cytotoxic for endothelial cells and LDL oxidation seems to be mediated by Fe (Jeney et al., 2002; Nagy et al., 2010). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

a(CHEBI:"oxidised LDL") increases path(HM:"Endothelial dysfunction") View Subject | View Object

Oxidized LP(ox- LP) then induces toxic effects in endothelial cells [6]. PubMed:26475040

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Abstract

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.