bp(MESH:"Cytotoxicity, Immunologic")
Thus, by participating in Fenton chemistry, non-transferrin-bound iron (i.e., iron not bound to the physiological iron transport protein, transferrin) causes oxidative damage, cytotoxicity and enhanced endothelial expression of adhesion molecules, thereby enhancing thrombotic risk (Hershko, 2007). PubMed:25307023
Heme/iron-mediated oxidative modification of LDL can cause endothelial cytotoxicity8,24 and – at sublethal doses – the expression of stress-response genes.9,11-14 PubMed:20378845
We have found that atheroma lipids when oxidized by heme are highly cytotoxic to human endothelial cells, and hemopexin reduced this cytotoxicity. PubMed:20378845
Pre-treatment of heme-oxidized lipids with glutathione/glutathione peroxidase reduced the lipid hydroperoxide content (113±30 vs. 74±22 nmol LOOH/mg extract, p<0.01) and inhibited the endothelial cell cytotoxicity by 25% (p<0.05). PubMed:20378845
These ROS then oxidize cell membrane constituents to induce cytotoxicity and promote inflammation and thrombosis. PubMed:25307023
Inhibition of lipid oxidation by either haptoglobin or hemopexin reduced the cytotoxicity (Fig 4B) and HO-1 induction caused by sublethal amounts of pretreated atheromatous lesion lipids (Fig 4C and D). PubMed:20378845
Heme/iron-mediated oxidative modification of LDL can cause endothelial cytotoxicity8,24 and – at sublethal doses – the expression of stress-response genes.9,11-14 PubMed:20378845
Inhibition of lipid oxidation by either haptoglobin or hemopexin reduced the cytotoxicity (Fig 4B) and HO-1 induction caused by sublethal amounts of pretreated atheromatous lesion lipids (Fig 4C and D). PubMed:20378845
Thus, by participating in Fenton chemistry, non-transferrin-bound iron (i.e., iron not bound to the physiological iron transport protein, transferrin) causes oxidative damage, cytotoxicity and enhanced endothelial expression of adhesion molecules, thereby enhancing thrombotic risk (Hershko, 2007). PubMed:25307023
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.