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p(PFAM:Ferritin)

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Entity

Name
Ferritin
Namespace
pfam
Namespace Version
20181024
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/pfam-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(CHEBI:"oxidised LDL") increases p(PFAM:Ferritin) View Subject | View Object

In previous studies we found that endothelial cells exposed to oxidized LDL upregulated both heme oxygenase-1 (HO-1) and ferritin,8,9 presumably as a defense mechanism.6,11-14 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell

a(CHEBI:"oxidised LDL") increases p(PFAM:Ferritin) View Subject | View Object

Upregulation of HO-115 and ferritin H chain16 in endothelial cells has been reported in the early phase of progression of atherosclerotic lesions. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis

a(HM:"Erythrocytes, lysed") positiveCorrelation act(p(PFAM:Ferritin)) View Subject | View Object

There was a marked increase in periventricular ferritin immunoreactivity after injection of lysed RBCs (Figure 3A) compared with saline or packed RBC injection. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

a(HM:"Erythrocytes, lysed") positiveCorrelation p(PFAM:Ferritin) View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

path(HP:"Intraventricular hemorrhage") positiveCorrelation p(PFAM:Ferritin) View Subject | View Object

In addition, iron and ferritin deposition are found in ependymal or subependymal location after neonatal IVH.7–9 PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Introduction

Out-Edges 3

p(PFAM:Ferritin) positiveCorrelation path(HP:"Intraventricular hemorrhage") View Subject | View Object

In addition, iron and ferritin deposition are found in ependymal or subependymal location after neonatal IVH.7–9 PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Introduction

act(p(PFAM:Ferritin)) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

There was a marked increase in periventricular ferritin immunoreactivity after injection of lysed RBCs (Figure 3A) compared with saline or packed RBC injection. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

p(PFAM:Ferritin) positiveCorrelation a(HM:"Erythrocytes, lysed") View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.