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p(RGD:Hmox1)

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Entity

Name
Hmox1
Namespace
rgd
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/rgd-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 7

a(CHEBI:"zinc protoporphyrin") decreases act(p(RGD:Hmox1)) View Subject | View Object

Fig. 4 shows that the inhibition of HO activity by both, SnPP (Fig. 4A) or ZnPP (Fig. 4B), potentiates the effect of heme on VSMC proliferation. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:"zinc protoporphyrin") decreases act(p(RGD:Hmox1)) View Subject | View Object

Additionally, it was observed that inhibition of HO-1 by ZnPP induced a further increase in hemeinduced ROS production (Fig. 4C), suggesting that activation of HO system attenuates the NADPHox-dependent activation of VSMC induced by heme. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:heme) increases p(RGD:Hmox1) View Subject | View Object

On the other hand, heme induced HO-1 expression in VSMC (Suppl. Fig. 2). PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(HM:"Erythrocytes, lysed") increases p(RGD:Hmox1) View Subject | View Object

There were many more periventricular HO-1-positive cells after injection of lysed RBCs than after saline or packed RBC injection. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

a(HM:"Erythrocytes, lysed") increases p(RGD:Hmox1) View Subject | View Object

HO-1 protein levels in the periventricular area were significantly increased in rats receiving lysed RBCs (3,566±2,481 pixels vs. 115±141 pixels in saline group and 295±311 pixels in the packed RBC group, Po0.05, Figure 2). PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Results

a(HM:"Erythrocytes, lysed") increases p(RGD:Hmox1) View Subject | View Object

The major findings of this study are (1) intraventricular injection of lysed RBCs but not packed RBCs resulted in hydrocephalus; (2) lysed RBCs upregulated brain HO-1 and ferritin levels; (3) intraventricular injection of iron also caused hydrocephalus; and (4) iron chelation with deferoxamine reduced lysed RBC-induced hydrocephalus. PubMed:24667910

Appears in Networks:
Annotations
MeSH
Ependyma
Text Location
Discussion

complex(a(CHEBI:"tin atom"), a(CHEBI:protoporphyrin)) decreases act(p(RGD:Hmox1)) View Subject | View Object

Fig. 4 shows that the inhibition of HO activity by both, SnPP (Fig. 4A) or ZnPP (Fig. 4B), potentiates the effect of heme on VSMC proliferation. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

Out-Edges 1

p(RGD:Hmox1) decreases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Additionally, it was observed that inhibition of HO-1 by ZnPP induced a further increase in hemeinduced ROS production (Fig. 4C), suggesting that activation of HO system attenuates the NADPHox-dependent activation of VSMC induced by heme. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.