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bp(MESH:Vasodilation)

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Entity

Name
Vasodilation
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(CHEBI:"carbon monoxide") increases bp(MESH:Vasodilation) View Subject | View Object

Carbon monoxide has vasodilatory, anti-proliferative, anti-inflammatory and antioxidant properties, whereas bilirubin, the product of biliverdin reductase, is an antioxidant (Baranano et al, 2002). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

a(CHEBI:"carbon monoxide") increases bp(MESH:Vasodilation) View Subject | View Object

This could be explained by the finding that CO induces vasodilation by binding to the heme-protein guanylyl cyclase [67]. PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Discussion

a(CHEBI:"iron(2+)") decreases bp(MESH:Vasodilation) View Subject | View Object

Thus, the antioxidant, anticoagulant, anti-proliferative and vasodilating effects of the HMOX1 and biliverdin reductase systems probably compensate for the nitric oxide (NO) scavenging, vasoconstrictive, proliferative, inflammatory and pro-oxidant effects of circulating free haemoglobin, haem and haem-iron, which are discussed below (Rother et al, 2005). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

a(CHEBI:heme) decreases bp(MESH:Vasodilation) View Subject | View Object

Thus, the antioxidant, anticoagulant, anti-proliferative and vasodilating effects of the HMOX1 and biliverdin reductase systems probably compensate for the nitric oxide (NO) scavenging, vasoconstrictive, proliferative, inflammatory and pro-oxidant effects of circulating free haemoglobin, haem and haem-iron, which are discussed below (Rother et al, 2005). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

p(HGNC:HBB) decreases bp(MESH:Vasodilation) View Subject | View Object

Thus, the antioxidant, anticoagulant, anti-proliferative and vasodilating effects of the HMOX1 and biliverdin reductase systems probably compensate for the nitric oxide (NO) scavenging, vasoconstrictive, proliferative, inflammatory and pro-oxidant effects of circulating free haemoglobin, haem and haem-iron, which are discussed below (Rother et al, 2005). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.