path(MESH:Hypertension)
Known envi- ronmental risk factors for LOAD include cardiovascular disease, and factors conferring a risk of cardiovascu- lar disease, such as diabetes mellitus and hypertension. Head trauma, physical and mental inactivity, and sleep impairment are additional risk factors for LOAD PubMed:26195256
Mecamylamine (Inversine®, Vecamyl®; Fig. 3) was developed over 60 years ago and marketed as a ganglionic blocker for the treatment of hypertension (e.g., [127]) PubMed:28391535
Moreover, heme-derived ROS induce the proliferation of smooth muscle cells, that participate in vasculopathy associated with atherosclerosis and hypertension [15]. PubMed:28400318
Intravenous infusion of cell-free hemoglobin induces hypertension in mice 205 (24). PubMed:28314763
One of the mechanisms by which cell-free hemoglobin exerts its detrimental effects is its ability to effectively scavenge nitric oxide (NO), which in turn leads to perfusion disorders and an increased arterial and pulmonary arterial pressure [39, 40]. PubMed:29956069
Recent data suggest that haptoglobin prevents hemoglobin-induced hypertension by 355 a similar mechanism (18). PubMed:28314763
In the 358 current study, we demonstrated that administration of human haptoglobin retained 359 cell-free hemoglobin in plasma, prevented hemoglobinuria, and reduced the 360 hemoglobin-induced hypertension in healthy awake mice (see Figure 1A). PubMed:28314763
These results 230 suggest that co-injection of haptoglobin but not hemopexin with cell-free hemoglobin 231 can prevent hemoglobin-induced hypertension in awake, healthy mice. PubMed:28314763
The classical findings that define PE are hypertension and proteinuria appearing after 20 weeks of gestation. PubMed:26368565
Known envi- ronmental risk factors for LOAD include cardiovascular disease, and factors conferring a risk of cardiovascu- lar disease, such as diabetes mellitus and hypertension. Head trauma, physical and mental inactivity, and sleep impairment are additional risk factors for LOAD PubMed:26195256
The classical findings that define PE are hypertension and proteinuria appearing after 20 weeks of gestation. PubMed:26368565
Moreover, heme-derived ROS induce the proliferation of smooth muscle cells, that participate in vasculopathy associated with atherosclerosis and hypertension [15]. PubMed:28400318
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