complex(a(MESH:"Blood Transfusion"), p(MGI:Hp))
Only transfusion of SRBCs and haptoglobin prevented SRBC-induced renal iron accumulation (Figure 6A and B). PubMed:27515135
In comparison to mice transfused with SRBCs alone, the spleens of mice resuscitated with SRBCs and haptoglobin contained more iron (Figure 6D). PubMed:27515135
In contrast, all of the mice survived after SRBC-transfusion and treatment with hemopexin (SRBC+Hx vs. SRBC+Alb, P=0.018). Similarly the survival rate of mice resuscitated with SRBCs and co-infusion of haptoglobin was 96% (SRBC+Hp vs. SRBC+Alb, P=0.030). PubMed:27515135
Co-administration of haptoglobin with SRBCs results in a prolonged increase in plasma hemoglobin levels for more than 48 hours after transfusion. PubMed:27515135
However, kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels and NGAL plasma concentrations in mice transfused with SRBCs and haptoglobin were lower than in mice transfused with SRBCs given a co-infusion of albumin (Figures 4C–F). PubMed:27515135
Resuscitation with SRBCs and haptoglobin prevented the increase in SRBC-induced renal HO-1 expression (Figure 7F). PubMed:27515135
Without adjusting for multiple comparison testing, IL-6 expression was lower in kidneys of mice resuscitated with SRBCs and haptoglobin compared to mice resuscitated with SRBCs and albumin (P<0.05). PubMed:27515135
However, kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels and NGAL plasma concentrations in mice transfused with SRBCs and haptoglobin were lower than in mice transfused with SRBCs given a co-infusion of albumin (Figures 4C–F). PubMed:27515135
The number of Ki-67 positive cells in kidneys from mice that received SRBCs and haptoglobin was similar to the number of Ki-67 positive cells in kidneys from mice that received FRBCs.. PubMed:27515135
Hemoglobinuria was present in mice resuscitated with SRBCs combined with albumin or hemopexin but not in mice resuscitated with SRBCs combined with haptoglobin (Figure 4A and B). PubMed:27515135
Co-infusion of haptoglobin but not albumin or hemopexin prevented SRBC-induced hemoglobinuria and kidney injury at 48 hours after resuscitation from hemorrhagic shock. PubMed:27515135
However, kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels and NGAL plasma concentrations in mice transfused with SRBCs and haptoglobin were lower than in mice transfused with SRBCs given a co-infusion of albumin (Figures 4C–F). PubMed:27515135
In contrast, all of the mice survived after SRBC-transfusion and treatment with hemopexin (SRBC+Hx vs. SRBC+Alb, P=0.018). Similarly the survival rate of mice resuscitated with SRBCs and co-infusion of haptoglobin was 96% (SRBC+Hp vs. SRBC+Alb, P=0.030). PubMed:27515135
Co-administration of haptoglobin with SRBCs results in a prolonged increase in plasma hemoglobin levels for more than 48 hours after transfusion. PubMed:27515135
Hemoglobinuria was present in mice resuscitated with SRBCs combined with albumin or hemopexin but not in mice resuscitated with SRBCs combined with haptoglobin (Figure 4A and B). PubMed:27515135
Co-infusion of haptoglobin but not albumin or hemopexin prevented SRBC-induced hemoglobinuria and kidney injury at 48 hours after resuscitation from hemorrhagic shock. PubMed:27515135
However, kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels and NGAL plasma concentrations in mice transfused with SRBCs and haptoglobin were lower than in mice transfused with SRBCs given a co-infusion of albumin (Figures 4C–F). PubMed:27515135
However, kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels and NGAL plasma concentrations in mice transfused with SRBCs and haptoglobin were lower than in mice transfused with SRBCs given a co-infusion of albumin (Figures 4C–F). PubMed:27515135
However, kidney KIM-1 and NGAL mRNA levels, urinary KIM-1 protein levels and NGAL plasma concentrations in mice transfused with SRBCs and haptoglobin were lower than in mice transfused with SRBCs given a co-infusion of albumin (Figures 4C–F). PubMed:27515135
The number of Ki-67 positive cells in kidneys from mice that received SRBCs and haptoglobin was similar to the number of Ki-67 positive cells in kidneys from mice that received FRBCs.. PubMed:27515135
Only transfusion of SRBCs and haptoglobin prevented SRBC-induced renal iron accumulation (Figure 6A and B). PubMed:27515135
In comparison to mice transfused with SRBCs alone, the spleens of mice resuscitated with SRBCs and haptoglobin contained more iron (Figure 6D). PubMed:27515135
Resuscitation with SRBCs and haptoglobin prevented the increase in SRBC-induced renal HO-1 expression (Figure 7F). PubMed:27515135
Without adjusting for multiple comparison testing, IL-6 expression was lower in kidneys of mice resuscitated with SRBCs and haptoglobin compared to mice resuscitated with SRBCs and albumin (P<0.05). PubMed:27515135
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.