1. Catalog
  2. Nodes
  3. p(MGI:Il6)

p(MGI:Il6)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Il6
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 3

Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation v1.0.0

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 12

a(CHEBI:Anatabine) decreases p(MGI:Il6) View Subject | View Object

Following 90 days of treatment with anatabine, a significant reduction in brain TNF-a (Mann–Whitney U=6, Z=-2.146, p=0.032) and in IL-6 (Mann–Whitney U=0, Z=-2.887, p=0.004) was observed in Tg APPsw mice compared to Tg APPsw that received regular drinking water (Fig. 9) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) View Subject | View Object

Our results showed that intraperitoneal injection of LPS (1 mg/kg) caused a significant elevation of plasma IL-1b (Mann–Whitney U=3, Z=-2.988, P=0.003), IL-6 (Mann–Whitney U=0, Z=-3.366, P=0.001) and TNFa (Mann– Whitney U=0, Z=-3.508, P<0.001) 4 h after the LPS challenge whereas in mice co-treated with an intraperitoneal injection of anatabine (2 mg/kg) and LPS, a significant reduction in plasma IL-1b (Mann–Whitney U=7, Z=-2.645, P=0.008) and TNFa (Mann–Whitney U=4, Z=-2.941, P=0.003) levels was observed (Fig. 6) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Plasma

a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) View Subject | View Object

An elevation of IL-6 (Mann–Whitney U=0, Z=-3.487, P<0.001), IL1b (Mann– Whitney U=0, Z=-3.24, P=0.001) and TNFa (Mann–Whitney U=0, Z=-3.361, P=0.001) was observed in the spleen of LPS challenged mice (Fig. 7) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Spleen

a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) View Subject | View Object

Similarly, IL-1b (Mann–Whitney U=0, Z=-3.098, P=0.002), IL-6 (Mann–Whitney U=0, Z=-3.363, P<0.001) and TNF-a levels (Mann–Whitney U=0, Z=-3.361, P=0.001) were elevated in the kidney following the LPS challenge (data not shown) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Kidney

composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) View Subject | View Object

Plasma IL-6 levels show a trend for a reduction but were not significantly affected (Mann–Whitney U=19, Z=-1.368, P=0.171) by the anatabine treatment (Fig. 6) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Plasma

composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) View Subject | View Object

Anatabine significantly inhibited LPS induced IL-6 (Mann–Whitney U=4, Z=-3.303, P=0.001), TNF-a (Mann–Whitney U=0, Z=-3.361, P=0.001) and IL-1b levels in the spleen (Mann–Whitney U=9, Z=-1.981, P=0.048) (Fig. 7) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Spleen

path(MESH:"Alzheimer Disease") increases p(MGI:Il6) View Subject | View Object

An elevation of brain IL-6 (Mann–Whitney U=0, Z=-3, p=0.003) and TNF-a (Mann–Whitney U=0, Z=-2.887, p=0.004) was observed in Tg APPsw mice compared to their wild-type littermates (Fig. 9) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

a(CHEBI:Anatabine) decreases p(MGI:Il6) View Subject | View Object

However, anatabine significantly suppressed the production of IL-1b, IL-6 and IL-17A in the serum of EAE mice (Fig. 2B) but did not significantly impact IFN-gamma and TNF-alpha PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum
MeSH
Encephalomyelitis

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il6) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

complex(a(MESH:"Blood Transfusion"), p(MGI:Alb)) positiveCorrelation p(MGI:Il6) View Subject | View Object

The renal expression level of IL-6 was greater 48 hours after resuscitation with SRBCs alone, SRBC and albumin, and SRBCs and hemopexin when compared to resuscitation with FRBCs (Supplemental Figure VI D). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) negativeCorrelation p(MGI:Il6) View Subject | View Object

Without adjusting for multiple comparison testing, IL-6 expression was lower in kidneys of mice resuscitated with SRBCs and haptoglobin compared to mice resuscitated with SRBCs and albumin (P<0.05). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) positiveCorrelation p(MGI:Il6) View Subject | View Object

The renal expression level of IL-6 was greater 48 hours after resuscitation with SRBCs alone, SRBC and albumin, and SRBCs and hemopexin when compared to resuscitation with FRBCs (Supplemental Figure VI D). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

Out-Edges 4

p(MGI:Il6) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

p(MGI:Il6) positiveCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) View Subject | View Object

The renal expression level of IL-6 was greater 48 hours after resuscitation with SRBCs alone, SRBC and albumin, and SRBCs and hemopexin when compared to resuscitation with FRBCs (Supplemental Figure VI D). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

p(MGI:Il6) positiveCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Alb)) View Subject | View Object

The renal expression level of IL-6 was greater 48 hours after resuscitation with SRBCs alone, SRBC and albumin, and SRBCs and hemopexin when compared to resuscitation with FRBCs (Supplemental Figure VI D). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

p(MGI:Il6) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hp)) View Subject | View Object

Without adjusting for multiple comparison testing, IL-6 expression was lower in kidneys of mice resuscitated with SRBCs and haptoglobin compared to mice resuscitated with SRBCs and albumin (P<0.05). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.