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complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx))

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Components

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 6

a(CHEBI:"iron(2+)") positiveCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) View Subject | View Object

Tissue iron staining revealed greater cortical iron accumulation in the kidneys of mice resuscitated with SRBCs, SRBCs combined with albumin and SRBCs combined with hemopexin than in the kidneys of mice transfused with FRBCs (Figure 6A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

a(CHEBI:heme) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) View Subject | View Object

These results demonstrate that transfusion with SRBCs and simultaneous infusion of exogenous hemopexin results in decreased levels of circulating cell-free heme. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

a(MESH:Mortality) negativeCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) View Subject | View Object

In contrast, all of the mice survived after SRBC-transfusion and treatment with hemopexin (SRBC+Hx vs. SRBC+Alb, P=0.018). Similarly the survival rate of mice resuscitated with SRBCs and co-infusion of haptoglobin was 96% (SRBC+Hp vs. SRBC+Alb, P=0.030). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

p(MGI:Hpx) positiveCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) View Subject | View Object

Infusion of hemopexin together with SRBCs resulted in a 6.4-fold (95% CI [5.2 – 7.6]) increase in plasma hemopexin levels at four hours after transfusion (Figure 3D). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

p(MGI:Hmox1) positiveCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) View Subject | View Object

Mice that were resuscitated with SRBCs and albumin or SRBCs and hemopexin showed a marked increase in HO-1 expression when compared to mice resuscitated with FRBCs. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

p(MGI:Il6) positiveCorrelation complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) View Subject | View Object

The renal expression level of IL-6 was greater 48 hours after resuscitation with SRBCs alone, SRBC and albumin, and SRBCs and hemopexin when compared to resuscitation with FRBCs (Supplemental Figure VI D). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

Out-Edges 8

complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) hasComponent a(MESH:"Blood Transfusion") View Subject | View Object

Appears in Networks:

complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) hasComponent p(MGI:Hpx) View Subject | View Object

Appears in Networks:

complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) positiveCorrelation p(MGI:Hpx) View Subject | View Object

Infusion of hemopexin together with SRBCs resulted in a 6.4-fold (95% CI [5.2 – 7.6]) increase in plasma hemopexin levels at four hours after transfusion (Figure 3D). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) negativeCorrelation a(MESH:Mortality) View Subject | View Object

In contrast, all of the mice survived after SRBC-transfusion and treatment with hemopexin (SRBC+Hx vs. SRBC+Alb, P=0.018). Similarly the survival rate of mice resuscitated with SRBCs and co-infusion of haptoglobin was 96% (SRBC+Hp vs. SRBC+Alb, P=0.030). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) negativeCorrelation a(CHEBI:heme) View Subject | View Object

These results demonstrate that transfusion with SRBCs and simultaneous infusion of exogenous hemopexin results in decreased levels of circulating cell-free heme. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

Tissue iron staining revealed greater cortical iron accumulation in the kidneys of mice resuscitated with SRBCs, SRBCs combined with albumin and SRBCs combined with hemopexin than in the kidneys of mice transfused with FRBCs (Figure 6A and B). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney Cortex
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) positiveCorrelation p(MGI:Il6) View Subject | View Object

The renal expression level of IL-6 was greater 48 hours after resuscitation with SRBCs alone, SRBC and albumin, and SRBCs and hemopexin when compared to resuscitation with FRBCs (Supplemental Figure VI D). PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

complex(a(MESH:"Blood Transfusion"), p(MGI:Hpx)) positiveCorrelation p(MGI:Hmox1) View Subject | View Object

Mice that were resuscitated with SRBCs and albumin or SRBCs and hemopexin showed a marked increase in HO-1 expression when compared to mice resuscitated with FRBCs. PubMed:27515135

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Hemorrhage
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.