Encephalomyelitis
In addition, anatabine markedly decreased the Iba1 immunostaining in the spinal cord of EAE mice showing that anatabine reduces the infiltration of macrophage/ microglia in the spinal cord of EAE mice (Fig. 10) PubMed:23383175
Importantly, approximately 70% of the mice in the placebo group developed hind-limb weakness or paralysis compared to only 20% in the anatabine treatment group (Fig. 1C) showing that the mice treated with anatabine displayed significantly milder disease symptoms than the placebo group PubMed:23383175
Interestingly, anatabine significantly prevented demyelination associated with EAE in the spinal cord (Fig. 12) PubMed:23383175
A marked increase in GFAP immunostaining was also observed in the spinal cord of EAE mice and was significantly suppressed by the anatabine treatment showing that anatabine prevents astrogliosis in the spinal cord of EAE mice (Fig. 11) PubMed:23383175
Interestingly, a significant reduction in the number of IBa1 immunopositive microglial cells was found in the hippocampus and medulla of anatabine treated EAE mice (Fig. 8) PubMed:23383175
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.