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bp(HBP:Astrogliosis)

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Entity

Name
Astrogliosis
Namespace
HBP
Namespace Version
20181221
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/bd0996a28201cad363557315043c6392e31abf58/export/hbp-names.belns

Appears in Networks 1

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine v1.0.0

In-Edges 5

a(CHEBI:Anatabine) causesNoChange bp(HBP:Astrogliosis) View Subject | View Object

Overall, anatabine did not significantly impact EAE induced astrogliosis for the different areas of the brain examined (Fig. 7) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Hippocampus

a(CHEBI:Anatabine) decreases bp(HBP:Astrogliosis) View Subject | View Object

A marked increase in GFAP immunostaining was also observed in the spinal cord of EAE mice and was significantly suppressed by the anatabine treatment showing that anatabine prevents astrogliosis in the spinal cord of EAE mice (Fig. 11) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord
MeSH
Encephalomyelitis

a(GO:"myelin sheath") negativeCorrelation bp(HBP:Astrogliosis) View Subject | View Object

A statistically significant positive correlation was observed between the amount of GFAP and Iba1 burden in the spinal cord (Pearson correlation = 0.612, P,0.002) whereas negative correlations were observed between the GFAP burden and the Luxol fast blue burden (Pearson correlation =20.525, P= 0.007), and between the IBa1 burden and the Luxol fast blue burden (Pearson correlation =20.609, P =0.001) suggesting that astrogliosis and microgliosis are associated with the loss of myelin in the spinal cord PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) View Subject | View Object

A significant increase in astrogliosis revealed by a GFAP immunostaining was observed in the cortex and medulla of EAE mice compared to control non immunized animals (Fig. 7) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) View Subject | View Object

A marked increase in GFAP immunostaining was also observed in the spinal cord of EAE mice and was significantly suppressed by the anatabine treatment showing that anatabine prevents astrogliosis in the spinal cord of EAE mice (Fig. 11) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

Out-Edges 1

bp(HBP:Astrogliosis) negativeCorrelation a(GO:"myelin sheath") View Subject | View Object

A statistically significant positive correlation was observed between the amount of GFAP and Iba1 burden in the spinal cord (Pearson correlation = 0.612, P,0.002) whereas negative correlations were observed between the GFAP burden and the Luxol fast blue burden (Pearson correlation =20.525, P= 0.007), and between the IBa1 burden and the Luxol fast blue burden (Pearson correlation =20.609, P =0.001) suggesting that astrogliosis and microgliosis are associated with the loss of myelin in the spinal cord PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.