1. Catalog
  2. Nodes
  3. path(MESH:Encephalomyelitis)

path(MESH:Encephalomyelitis)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Encephalomyelitis
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine v1.0.0

In-Edges 10

a(CHEBI:Anatabine) negativeCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

Clinical signs of EAE became apparent by day 6 following the immunization in the placebo group but were delayed to day 11 in the anatabine treatment group (Fig. 1A) PubMed:23383175

Appears in Networks:

a(CHEBI:Anatabine) decreases path(MESH:Encephalomyelitis) View Subject | View Object

The average clinical severity of EAE was also significantly reduced by the anatabine treatment (Fig. 1B) PubMed:23383175

Appears in Networks:

p(MGI:Ifng) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

p(MGI:Il17a) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

p(MGI:Il1b) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

p(MGI:Il6) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

Interestingly, a statistically significant correlation was observed between the amount of STAT3 phosphorylation detected in brain homogenates and the clinical severity of EAE (Pearson correlation = 0.653, P<0.001) but not with p65 NFkB phosphorylation (Pearson correlation = 0.371, P= 0.062) suggesting that STAT3 may play a more preponderant role than NFkB in the development of neurological deficits of EAE PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

A statistically significant correlation was observed between the number of STAT3 phosphorylated cells in the cerebral cortex and the clinical severity of EAE (Pearson Correlation =0.531, P,0.002) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

A statistically significant correlation was also observed between the amount of STAT3 phosphorylated cells in the spinal cord and the clinical severity of EAE (Pearson Correlation = 0.512, P,0.004) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

p(MGI:Tnf) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

Out-Edges 23

path(MESH:Encephalomyelitis) negativeCorrelation a(CHEBI:Anatabine) View Subject | View Object

Clinical signs of EAE became apparent by day 6 following the immunization in the placebo group but were delayed to day 11 in the anatabine treatment group (Fig. 1A) PubMed:23383175

Appears in Networks:

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il1b) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

path(MESH:Encephalomyelitis) increases p(MGI:Il1b) View Subject | View Object

A significant elevation of IL-1b, INF-gamma and TNF-alpha was observed in the spleen of EAE mice compared to control non immunized animals PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spleen

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Ifng) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

path(MESH:Encephalomyelitis) increases p(MGI:Ifng) View Subject | View Object

A significant elevation of IL-1b, INF-gamma and TNF-alpha was observed in the spleen of EAE mice compared to control non immunized animals PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spleen

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Tnf) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

path(MESH:Encephalomyelitis) increases p(MGI:Tnf) View Subject | View Object

A significant elevation of IL-1b, INF-gamma and TNF-alpha was observed in the spleen of EAE mice compared to control non immunized animals PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spleen

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il6) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il17a) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Interestingly, a significant increase in STAT3 phosphorylation was observed in the spleen of EAE mice compared to control non immunized mice and a significant decrease in STAT3 phosphorylation level was detected in EAE mice treated with anatabine (Fig. 3) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spleen

path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Western-blot experiments using brain homogenates from EAE mice also reveal that both STAT3 and p65 NFkB phosphorylation are significantly elevated in the brain of EAE mice compared to control non immunized mice (Fig. 4) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Interestingly, a statistically significant correlation was observed between the amount of STAT3 phosphorylation detected in brain homogenates and the clinical severity of EAE (Pearson correlation = 0.653, P<0.001) but not with p65 NFkB phosphorylation (Pearson correlation = 0.371, P= 0.062) suggesting that STAT3 may play a more preponderant role than NFkB in the development of neurological deficits of EAE PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

We further assessed STAT3 phosphorylation by immunohistochemistry using brain sections of the animals and observed an increased number of phosphorylated STAT3 immunopositive cells in the cortex of EAE mice compared to control non-immunized mice (Fig. 5) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Similarly, we observed an increased number of phosphorylated STAT3 immunopositive cells in the spinal cord of EAE mice compared to control non-immunized mice and a decreased number of phosphorylated STAT3 immunoreactive cells in EAE mice treated with anatabine (Fig. 6) showing overall that anatabine reduces STAT3 phosphorylation in the brain, spinal cord and spleen of EAE mice. PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) View Subject | View Object

A statistically significant correlation was observed between the number of STAT3 phosphorylated cells in the cerebral cortex and the clinical severity of EAE (Pearson Correlation =0.531, P,0.002) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) View Subject | View Object

A statistically significant correlation was also observed between the amount of STAT3 phosphorylated cells in the spinal cord and the clinical severity of EAE (Pearson Correlation = 0.512, P,0.004) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

path(MESH:Encephalomyelitis) increases p(MGI:Rela, pmod(Ph)) View Subject | View Object

Western-blot experiments using brain homogenates from EAE mice also reveal that both STAT3 and p65 NFkB phosphorylation are significantly elevated in the brain of EAE mice compared to control non immunized mice (Fig. 4) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) View Subject | View Object

A significant increase in astrogliosis revealed by a GFAP immunostaining was observed in the cortex and medulla of EAE mice compared to control non immunized animals (Fig. 7) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) View Subject | View Object

A marked increase in GFAP immunostaining was also observed in the spinal cord of EAE mice and was significantly suppressed by the anatabine treatment showing that anatabine prevents astrogliosis in the spinal cord of EAE mice (Fig. 11) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

path(MESH:Encephalomyelitis) increases bp(HBP:Microgliosis) View Subject | View Object

A significant increase in the number of microglial cells immunoreactive for Iba1 was observed in the hippocampus and medulla of EAE mice compared to control non-immunized mice (Fig. 8) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Medulla Oblongata

path(MESH:Encephalomyelitis) increases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) View Subject | View Object

As shown in Fig. 9, hematoxylin and eosin staining revealed numerous perivascular clusters of mononuclear infiltrating cells in the spinal cord of EAE mice and an absence of these inflammatory cell infiltrates in the spinal cord of control non-immunized mice PubMed:23383175

Appears in Networks:

path(MESH:Encephalomyelitis) increases a(MESH:Microglia) View Subject | View Object

Globally, Iba1 immunostaining is significantly increased in the spinal cord of EAE mice compared to control nonimmunized mice (Fig. 10) PubMed:23383175

Appears in Networks:

path(MESH:Encephalomyelitis) decreases a(GO:"myelin sheath") View Subject | View Object

Finally, Luxol Fast Blue staining showed significant myelin loss in the white matter of the spinal cord of EAE mice compared control non-immunized mice (Fig. 12) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord
MeSH
White Matter

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.