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p(MGI:Stat3, pmod(Ph))

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Entity

Name
Stat3
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 2

Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation v1.0.0

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine v1.0.0

In-Edges 19

a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Western-blot experiments revealed that LPS significantly stimulated of STAT3 phosphorylation in the spleen (Mann–Whitney U=0, Z=-2.309, P=0.021) (Fig. 8) and kidney (Mann–Whitney U=0, Z=-2.882, P=0.004) (data not shown) whereas anatabine significantly inhibited STAT3 phosphorylation in the spleen (Mann–Whitney U=1, Z=-2.021, P=0.043) and kidney (Mann– Whitney U=5, Z=-2.082, P=0.037) (data not shown) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Spleen

a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

A significant elevation of STAT3 phosphorylation was detected in the brain of Tg APPsw compared to their control littermates (Mann–Whitney U=1, Z=-3.767, p<0.001) and a significant reduction in STAT3 phosphorylation (Mann–Whitney U=8, Z=-2.066, p=0.039) was observed in the brain of Tg APPsw treated with anatabine compared to untreated Tg APPsw littermates (Fig. 10). PubMed:23178521

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

a(CHEBI:lipopolysaccharide) increases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Western-blot experiments revealed that LPS significantly stimulated of STAT3 phosphorylation in the spleen (Mann–Whitney U=0, Z=-2.309, P=0.021) (Fig. 8) and kidney (Mann–Whitney U=0, Z=-2.882, P=0.004) (data not shown) whereas anatabine significantly inhibited STAT3 phosphorylation in the spleen (Mann–Whitney U=1, Z=-2.021, P=0.043) and kidney (Mann– Whitney U=5, Z=-2.082, P=0.037) (data not shown) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Spleen

p(MGI:Stat3) hasVariant p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

A significant elevation of STAT3 phosphorylation was detected in the brain of Tg APPsw compared to their control littermates (Mann–Whitney U=1, Z=-3.767, p<0.001) and a significant reduction in STAT3 phosphorylation (Mann–Whitney U=8, Z=-2.066, p=0.039) was observed in the brain of Tg APPsw treated with anatabine compared to untreated Tg APPsw littermates (Fig. 10). PubMed:23178521

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

We have shown previously that anatabine prevents STAT3 and p65 NFkB phosphorylation in various cell types and suggested that anatabine impact cytokine production by this mechanism as both STAT3 and p65 NFkB are known to regulate cytokine production. PubMed:23383175

Appears in Networks:

a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Interestingly, a significant increase in STAT3 phosphorylation was observed in the spleen of EAE mice compared to control non immunized mice and a significant decrease in STAT3 phosphorylation level was detected in EAE mice treated with anatabine (Fig. 3) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spleen
MeSH
Encephalomyelitis

a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Additionally, we observed that anatabine significantly prevented STAT3 and p65 NFkB phosphorylation in brain homogenates of EAE mice (Fig. 4) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Encephalomyelitis

a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

A reduction in the number of phosphorylated STAT3 immunoreactive cells was observed in the cerebral cortex of EAE mice treated with anatabine further confirming the data obtained by western-blotting using brain homogenates (Fig. 5) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Encephalomyelitis

a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Similarly, we observed an increased number of phosphorylated STAT3 immunopositive cells in the spinal cord of EAE mice compared to control non-immunized mice and a decreased number of phosphorylated STAT3 immunoreactive cells in EAE mice treated with anatabine (Fig. 6) showing overall that anatabine reduces STAT3 phosphorylation in the brain, spinal cord and spleen of EAE mice. PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord
MeSH
Encephalomyelitis

p(MGI:Rela, pmod(Ph)) positiveCorrelation p(MGI:Stat3, pmod(Ph)) View Subject | View Object

In addition, we observed a statistically significant correlation between the amount of p65 NFkB phosphorylation and STAT3 phosphorylation in brain homogenates (Pearson Correlation = 0.637, P<0.001) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Neurologic Manifestations") association p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Interestingly, a statistically significant correlation was observed between the amount of STAT3 phosphorylation detected in brain homogenates and the clinical severity of EAE (Pearson correlation = 0.653, P<0.001) but not with p65 NFkB phosphorylation (Pearson correlation = 0.371, P= 0.062) suggesting that STAT3 may play a more preponderant role than NFkB in the development of neurological deficits of EAE PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Interestingly, a significant increase in STAT3 phosphorylation was observed in the spleen of EAE mice compared to control non immunized mice and a significant decrease in STAT3 phosphorylation level was detected in EAE mice treated with anatabine (Fig. 3) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spleen

path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Western-blot experiments using brain homogenates from EAE mice also reveal that both STAT3 and p65 NFkB phosphorylation are significantly elevated in the brain of EAE mice compared to control non immunized mice (Fig. 4) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Interestingly, a statistically significant correlation was observed between the amount of STAT3 phosphorylation detected in brain homogenates and the clinical severity of EAE (Pearson correlation = 0.653, P<0.001) but not with p65 NFkB phosphorylation (Pearson correlation = 0.371, P= 0.062) suggesting that STAT3 may play a more preponderant role than NFkB in the development of neurological deficits of EAE PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

We further assessed STAT3 phosphorylation by immunohistochemistry using brain sections of the animals and observed an increased number of phosphorylated STAT3 immunopositive cells in the cortex of EAE mice compared to control non-immunized mice (Fig. 5) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Similarly, we observed an increased number of phosphorylated STAT3 immunopositive cells in the spinal cord of EAE mice compared to control non-immunized mice and a decreased number of phosphorylated STAT3 immunoreactive cells in EAE mice treated with anatabine (Fig. 6) showing overall that anatabine reduces STAT3 phosphorylation in the brain, spinal cord and spleen of EAE mice. PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) View Subject | View Object

A statistically significant correlation was observed between the number of STAT3 phosphorylated cells in the cerebral cortex and the clinical severity of EAE (Pearson Correlation =0.531, P,0.002) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) View Subject | View Object

A statistically significant correlation was also observed between the amount of STAT3 phosphorylated cells in the spinal cord and the clinical severity of EAE (Pearson Correlation = 0.512, P,0.004) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

Out-Edges 5

p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

Interestingly, a statistically significant correlation was observed between the amount of STAT3 phosphorylation detected in brain homogenates and the clinical severity of EAE (Pearson correlation = 0.653, P<0.001) but not with p65 NFkB phosphorylation (Pearson correlation = 0.371, P= 0.062) suggesting that STAT3 may play a more preponderant role than NFkB in the development of neurological deficits of EAE PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

A statistically significant correlation was observed between the number of STAT3 phosphorylated cells in the cerebral cortex and the clinical severity of EAE (Pearson Correlation =0.531, P,0.002) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

A statistically significant correlation was also observed between the amount of STAT3 phosphorylated cells in the spinal cord and the clinical severity of EAE (Pearson Correlation = 0.512, P,0.004) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

p(MGI:Stat3, pmod(Ph)) association path(MESH:"Neurologic Manifestations") View Subject | View Object

Interestingly, a statistically significant correlation was observed between the amount of STAT3 phosphorylation detected in brain homogenates and the clinical severity of EAE (Pearson correlation = 0.653, P<0.001) but not with p65 NFkB phosphorylation (Pearson correlation = 0.371, P= 0.062) suggesting that STAT3 may play a more preponderant role than NFkB in the development of neurological deficits of EAE PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

p(MGI:Stat3, pmod(Ph)) positiveCorrelation p(MGI:Rela, pmod(Ph)) View Subject | View Object

In addition, we observed a statistically significant correlation between the amount of p65 NFkB phosphorylation and STAT3 phosphorylation in brain homogenates (Pearson Correlation = 0.637, P<0.001) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.