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bp(HBP:Microgliosis)

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Entity

Name
Microgliosis
Namespace
HBP
Namespace Version
20181221
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/bd0996a28201cad363557315043c6392e31abf58/export/hbp-names.belns

Appears in Networks 2

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine v1.0.0

Anatabine Attenuates Tau Phosphorylation and Oligomerization in P301S Tau Transgenic Mice v1.0.0

In-Edges 4

a(CHEBI:Anatabine) decreases bp(HBP:Microgliosis) View Subject | View Object

Interestingly, a significant reduction in the number of IBa1 immunopositive microglial cells was found in the hippocampus and medulla of anatabine treated EAE mice (Fig. 8) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Medulla Oblongata
MeSH
Encephalomyelitis

a(GO:"myelin sheath") negativeCorrelation bp(HBP:Microgliosis) View Subject | View Object

A statistically significant positive correlation was observed between the amount of GFAP and Iba1 burden in the spinal cord (Pearson correlation = 0.612, P,0.002) whereas negative correlations were observed between the GFAP burden and the Luxol fast blue burden (Pearson correlation =20.525, P= 0.007), and between the IBa1 burden and the Luxol fast blue burden (Pearson correlation =20.609, P =0.001) suggesting that astrogliosis and microgliosis are associated with the loss of myelin in the spinal cord PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

path(MESH:Encephalomyelitis) increases bp(HBP:Microgliosis) View Subject | View Object

A significant increase in the number of microglial cells immunoreactive for Iba1 was observed in the hippocampus and medulla of EAE mice compared to control non-immunized mice (Fig. 8) PubMed:23383175

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Medulla Oblongata

a(CHEBI:Anatabine) decreases bp(HBP:Microgliosis) View Subject | View Object

A significant reduction in Iba1 immunoreactivity was observed both in the brain (T-test, P<0.01) and spinal cord (T-test, P<0.01) homogenates of Tg Tau P301S mice treated with anatabine. Figure 10. DOI:10.4172/2168-975X.1000126

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Spinal Cord

Out-Edges 1

bp(HBP:Microgliosis) negativeCorrelation a(GO:"myelin sheath") View Subject | View Object

A statistically significant positive correlation was observed between the amount of GFAP and Iba1 burden in the spinal cord (Pearson correlation = 0.612, P,0.002) whereas negative correlations were observed between the GFAP burden and the Luxol fast blue burden (Pearson correlation =20.525, P= 0.007), and between the IBa1 burden and the Luxol fast blue burden (Pearson correlation =20.609, P =0.001) suggesting that astrogliosis and microgliosis are associated with the loss of myelin in the spinal cord PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spinal Cord

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.